SLC5A8

Solute carrier family 5 (iodide transporter), member 8
Identifiers
Symbol(s)	SLC5A8; AIT; MGC125354; SMCT
External IDs	OMIM: 608044 MGI: 2384916 Homologene: 64832
Gene ontology Molecular Function: • transporter activity Cellular Component: • membrane • integral to membrane Biological Process: • ion transport • sodium ion transport
RNA expression pattern
250px 250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	160728	216225
Ensembl	ENSG00000139357	na
Refseq	NM_145913 (mRNA) NP_666018 (protein)	XM_001001565 (mRNA) XP_001001565 (protein)
Location	Chr 12: 100.07 - 100.13 Mb	na
Pubmed search	[1]	[2]

Solute carrier family 5 (iodide transporter), member 8, also known as SLC5A8, is a human gene.

See also

• Solute carrier family

Further reading

• Gupta N, Martin PM, Prasad PD, Ganapathy V (2006). "SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter.". Life Sci. 78 (21): 2419-25. doi:10.1016/j.lfs.2005.10.028. PMID 16375929.
• Rodriguez AM, Perron B, Lacroix L, et al. (2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.". J. Clin. Endocrinol. Metab. 87 (7): 3500-3. PMID 12107270.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Li H, Myeroff L, Smiraglia D, et al. (2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8412-7. doi:10.1073/pnas.1430846100. PMID 12829793.
• Miyauchi S, Gopal E, Fei YJ, Ganapathy V (2004). "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.". J. Biol. Chem. 279 (14): 13293-6. doi:10.1074/jbc.C400059200. PMID 14966140.
• Lacroix L, Pourcher T, Magnon C, et al. (2004). "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters.". J. Clin. Endocrinol. Metab. 89 (3): 1423-8. PMID 15001644.
• Hong C, Maunakea A, Jun P, et al. (2005). "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.". Cancer Res. 65 (9): 3617-23. doi:10.1158/0008-5472.CAN-05-0048. PMID 15867356.
• Paroder V, Spencer SR, Paroder M, et al. (2006). "Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7270-5. doi:10.1073/pnas.0602365103. PMID 16670197.
• Hu S, Liu D, Tufano RP, et al. (2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer.". Int. J. Cancer 119 (10): 2322-9. doi:10.1002/ijc.22110. PMID 16858683.
• Gopal E, Miyauchi S, Martin PM, et al. (2007). "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract.". Pharm. Res. 24 (3): 575-84. doi:10.1007/s11095-006-9176-1. PMID 17245649.
• Coady MJ, Wallendorff B, Bourgeois F, et al. (2007). "Establishing a definitive stoichiometry for the Na+/monocarboxylate cotransporter SMCT1.". Biophys. J. 93 (7): 2325-31. doi:10.1529/biophysj.107.108555. PMID 17526579.