SLC4A3

Solute carrier family 4, anion exchanger, member 3
Identifiers
Symbol(s)	SLC4A3; AE3; SLC2C
External IDs	OMIM: 106195 MGI: 109350 Homologene: 38005
Gene ontology Molecular Function: • inorganic anion exchanger activity • antiporter activity Cellular Component: • membrane fraction • integral to plasma membrane • membrane • integral to membrane Biological Process: • anion transport
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6508	20536
Ensembl	ENSG00000114923	ENSMUSG00000006576
Uniprot	P48751	Q68EG4
Refseq	NM_005070 (mRNA) NP_005061 (protein)	NM_009208 (mRNA) NP_033234 (protein)
Location	Chr 2: 220.2 - 220.21 Mb	Chr 1: 75.43 - 75.44 Mb
Pubmed search	[1]	[2]

Solute carrier family 4, anion exchanger, member 3, also known as SLC4A3, is a human gene.

See also

• Solute carrier family

Further reading

• Alper SL, Chernova MN, Stewart AK (2002). "Regulation of Na+-independent Cl-/HCO3- exchangers by pH.". JOP 2 (4 Suppl): 171-5. PMID 11875255.
• Alper SL, Darman RB, Chernova MN, Dahl NK (2002). "The AE gene family of Cl/HCO3- exchangers.". J. Nephrol. 15 Suppl 5: S41-53. PMID 12027221.
• Kopito RR, Lee BS, Simmons DM, et al. (1990). "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger.". Cell 59 (5): 927-37. PMID 2686841.
• Yannoukakos D, Stuart-Tilley A, Fernandez HA, et al. (1994). "Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.". Circ. Res. 75 (4): 603-14. PMID 7923606.
• Su YR, Klanke CA, Houseal TW, et al. (1995). "Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36.". Genomics 22 (3): 605-9. doi:10.1006/geno.1994.1433. PMID 8001971.
• Morgans CW, Kopito RR (1993). "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin.". J. Cell. Sci. 105 ( Pt 4): 1137-42. PMID 8227202.
• Dudeja PK, Hafez N, Tyagi S, et al. (1999). "Expression of the Na+/H+ and Cl-/HCO-3 exchanger isoforms in proximal and distal human airways.". Am. J. Physiol. 276 (6 Pt 1): L971-8. PMID 10362722.
• Einum DD, Zhang J, Arneson PJ, et al. (2000). "Genomic structure of human anion exchanger 3 and its potential role in hereditary neurological disease.". Neurogenetics 1 (4): 289-92. PMID 10732805.
• Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.". Am. J. Physiol. Renal Physiol. 280 (2): F356-64. PMID 11208611.
• Alrefai WA, Tyagi S, Nazir TM, et al. (2001). "Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.". Biochim. Biophys. Acta 1511 (1): 17-27. PMID 11248201.
• Sterling D, Reithmeier RA, Casey JR (2002). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers.". J. Biol. Chem. 276 (51): 47886-94. doi:10.1074/jbc.M105959200. PMID 11606574.
• Alvarez BV, Fujinaga J, Casey JR (2002). "Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium.". Circ. Res. 89 (12): 1246-53. PMID 11739292.
• Wang Z, Petrovic S, Mann E, Soleimani M (2002). "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G573-9. doi:10.1152/ajpgi.00338.2001. PMID 11842009.
• Al-Bazzaz FJ, Hafez N, Tyagi S, et al. (2002). "Detection of Cl--HCO3- and Na+-H+ exchangers in human airways epithelium.". JOP 2 (4 Suppl): 285-90. PMID 11875273.
• Sterling D, Alvarez BV, Casey JR (2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV.". J. Biol. Chem. 277 (28): 25239-46. doi:10.1074/jbc.M202562200. PMID 11994299.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.