SLC2A9

Solute carrier family 2 (facilitated glucose transporter), member 9
Identifiers
Symbol(s)	SLC2A9; GLUT9; GLUTX
External IDs	OMIM: 606142 MGI: 2152844 Homologene: 69290
Gene ontology Molecular Function: • transporter activity • sugar:hydrogen ion symporter activity • glucose transmembrane transporter activity Cellular Component: • nuclear envelope • plasma membrane • integral to plasma membrane • membrane • integral to membrane Biological Process: • carbohydrate transport • glucose transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	56606	117591
Ensembl	ENSG00000109667	ENSMUSG00000005107
Uniprot	Q9NRM0	na
Refseq	NM_001001290 (mRNA) NP_001001290 (protein)	NM_001012363 (mRNA) NP_001012363 (protein)
Location	Chr 4: 9.44 - 9.65 Mb	Chr 5: 38.64 - 38.79 Mb
Pubmed search	[1]	[2]

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

Overview

Solute carrier family 2 (facilitated glucose transporter), member 9, also known as SLC2A9, is a human gene.

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.

SLC2A9 has also recently been found to transport uric acid and genetic variants of the transporter have been linked to increased risk of development of gout.

See also

• Glucose transporter
• Solute carrier family

Further reading

• Phay JE, Hussain HB, Moley JF (2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).". Genomics 66 (2): 217-20. doi:10.1006/geno.2000.6195. PMID 10860667.
• Doege H, Bocianski A, Joost HG, Schürmann A (2001). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.". Biochem. J. 350 Pt 3: 771-6. PMID 10970791.
• Shikhman AR, Brinson DC, Valbracht J, Lotz MK (2001). "Cytokine regulation of facilitated glucose transport in human articular chondrocytes.". J. Immunol. 167 (12): 7001-8. PMID 11739520.
• Mobasheri A, Neama G, Bell S, et al. (2002). "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9.". Cell Biol. Int. 26 (3): 297-300. doi:10.1006/cbir.2001.0850. PMID 11991658.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.". Osteoarthr. Cartil. 11 (2): 92-101. PMID 12554125.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Augustin R, Carayannopoulos MO, Dowd LO, et al. (2004). "Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking.". J. Biol. Chem. 279 (16): 16229-36. doi:10.1074/jbc.M312226200. PMID 14739288.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.