SLC23A2

Solute carrier family 23 (nucleobase transporters), member 2
Identifiers
Symbol(s)	SLC23A2; KIAA0238; NBTL1; SLC23A1; SVCT2; YSPL2
External IDs	OMIM: 603791 MGI: 1859682 Homologene: 68440
Gene ontology Molecular Function: • transporter activity • L-ascorbate:sodium symporter activity • sodium-dependent multivitamin transmembrane transporter activity • nucleobase transmembrane transporter activity • symporter activity • sodium ion binding Cellular Component: • membrane fraction • integral to plasma membrane • membrane Biological Process: • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • ion transport • sodium ion transport • nucleobase transport • molecular hydrogen transport • L-ascorbic acid metabolic process
RNA expression pattern
250px 250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	9962	54338
Ensembl	ENSG00000089057	ENSMUSG00000027340
Uniprot	Q9UGH3	Q3TDU7
Refseq	NM_005116 (mRNA) NP_005107 (protein)	NM_018824 (mRNA) NP_061294 (protein)
Location	Chr 20: 4.78 - 4.94 Mb	Chr 2: 131.74 - 131.84 Mb
Pubmed search	[1]	[2]

Solute carrier family 23 (nucleobase transporters), member 2, also known as SLC23A2, is a human gene.

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.

See also

• Solute carrier family

Further reading

• Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells.". Mol. Membr. Biol. 18 (1): 87-95. PMID 11396616.
• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321-9, 341-54. PMID 9039502.
• Faaland CA, Race JE, Ricken G, et al. (1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.". Biochim. Biophys. Acta 1442 (2-3): 353-60. PMID 9804989.
• Tsukaguchi H, Tokui T, Mackenzie B, et al. (1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters.". Nature 399 (6731): 70-5. doi:10.1038/19986. PMID 10331392.
• Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.". Genomics 59 (1): 18-23. doi:10.1006/geno.1999.5847. PMID 10395795.
• Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.". Biochem. Biophys. Res. Commun. 262 (3): 762-8. doi:10.1006/bbrc.1999.1272. PMID 10471399.
• Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.". FEBS Lett. 460 (3): 480-4. PMID 10556521.
• Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.". J. Biol. Chem. 275 (24): 18219-24. doi:10.1074/jbc.M909857199. PMID 10748165.
• Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.". J. Biol. Chem. 275 (41): 32331-7. doi:10.1074/jbc.M004795200. PMID 10915794.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
• Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445-6. doi:10.1038/nm0502-445. PMID 11984580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Fischer H, Schwarzer C, Illek B (2004). "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691-6. doi:10.1073/pnas.0308393100. PMID 14993613.
• Lutsenko EA, Carcamo JM, Golde DW (2004). "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport.". Mol. Cell. Biol. 24 (8): 3150-6. PMID 15060139.
• Seno T, Inoue N, Matsui K, et al. (2004). "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells.". J. Vasc. Res. 41 (4): 345-51. doi:10.1159/000080525. PMID 15340249.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• McNulty AL, Vail TP, Kraus VB (2005). "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.". Biochim. Biophys. Acta 1712 (2): 212-21. doi:10.1016/j.bbamem.2005.04.009. PMID 15921655.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.