SLC7A3

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
Identifiers
Symbol(s)	SLC7A3; ATRC3; CAT-3; FLJ14541; MGC20687
External IDs	OMIM: 300443 MGI: 1100521 Homologene: 56382
Gene ontology Molecular Function: • arginine transmembrane transporter activity • L-lysine transmembrane transporter activity • cationic amino acid transmembrane transporter activity • amino acid transmembrane transporter activity Cellular Component: • membrane • integral to membrane Biological Process: • transport • amino acid transport • arginine transport • lysine transport
Orthologs
	Human	Mouse
Entrez	84889	11989
Ensembl	ENSG00000165349	ENSMUSG00000031297
Uniprot	Q8WY07	Q3TMH5
Refseq	NM_001048164 (mRNA) NP_001041629 (protein)	NM_007515 (mRNA) NP_031541 (protein)
Location	Chr X: 70.06 - 70.07 Mb	Chr X: 97.28 - 97.29 Mb
Pubmed search	[1]	[2]

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3, also known as SLC7A3, is a human gene.

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM]

See also

• Solute carrier family

Further reading

• Hosokawa H, Sawamura T, Kobayashi S, et al. (1997). "Cloning and characterization of a brain-specific cationic amino acid transporter.". J. Biol. Chem. 272 (13): 8717-22. PMID 9079705.
• Ito K, Groudine M (1997). "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.". J. Biol. Chem. 272 (42): 26780-6. PMID 9334265.
• Hosokawa H, Ninomiya H, Sawamura T, et al. (1999). "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.". Brain Res. 838 (1-2): 158-65. PMID 10446328.
• Vékony N, Wolf S, Boissel JP, et al. (2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.". Biochemistry 40 (41): 12387-94. PMID 11591158.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Gilles W, Vulcu SD, Liewald JF, et al. (2005). "Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3.". Biochim. Biophys. Acta 1668 (2): 234-9. doi:10.1016/j.bbamem.2004.12.011. PMID 15737334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rotmann A, Vékony N, Gassner D, et al. (2006). "Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane.". Biochem. J. 395 (1): 117-23. doi:10.1042/BJ20051558. PMID 16332251.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.