Iron overload disorder

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Iron overload disorder Classification and external resources
ICD-10	R79.0
ICD-9	790.6

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Evidence Based Medicine
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Overview

In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.^[1]

Causes

The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).^[1]

Primary iron overload

Description	OMIM	Mutation
Haemochromatosis type 1: "classical"-haemochromatosis	235200	HFE
Haemochromatosis type 2A: juvenile haemochromatosis	602390	hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis	606464	hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3	604720	transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4	604653	ferroportin (SLC11A3)
Neonatal haemochromatosis	231100	(unknown)
Aceruloplasminaemia (rare disease)	604290	ceruloplasmin
Congenital atransferrinaemia (rare disease)	209300	transferrin

Secondary iron overload

• Dietary iron overload
• Transfusional iron overload
• Long term haemodialysis
• Chronic liver disease
  • Hepatitis C
  • Alcoholic cirrhosis, especially when advanced
  • Non-alcoholic steatohepatitis
• Porphyria cutanea tarda
• Post-portacaval shunting
• Dysmetabolic iron overload syndrome

Miscellaneous

The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online 'Mendelian Inheritance in Man' (OMIM) 601195)

See also

• Iron deficiency
• Siderosis
• Human iron metabolism

References

External links

• Texas Medical Center
• Merck
• Iron Overload.org

v • d • e WikiDoc Research Resources for Iron overload disorder
Articles on Iron overload disorder	Most recent articles on Iron overload disorder • Most cited articles on Iron overload disorder • Review articles on Iron overload disorder • Articles on Iron overload disorder in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Iron overload disorder	Powerpoint slides on Iron overload disorder • Images of Iron overload disorder • Photos of Iron overload disorder • Podcasts & MP3s on Iron overload disorder • Videos on Iron overload disorder
Evidence Based Medicine Regarding Iron overload disorder	Cochrane Collaboration on Iron overload disorder • Bandolier on Iron overload disorder • TRIP on Iron overload disorder
Cost Effectiveness of Iron overload disorder	Cost Effectiveness of Iron overload disorder
Clinical Trials Involving Iron overload disorder	Ongoing Trials on Iron overload disorder at Clinical Trials.gov • Trial results on Iron overload disorder • Clinical Trials on Iron overload disorder at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Iron overload disorder	US National Guidelines Clearinghouse on Iron overload disorder • NICE Guidance on Iron overload disorder • NHS PRODIGY Guidance • FDA on Iron overload disorder • CDC on Iron overload disorder
Textbook Information on Iron overload disorder	Books and Textbook Information on Iron overload disorder
Pharmacology Resources on Iron overload disorder	Dosing of Iron overload disorder • Drug interactions with Iron overload disorder • Side effects of Iron overload disorder • Allergic reactions to Iron overload disorder • Overdose information on Iron overload disorder • Carcinogenicity information on Iron overload disorder • Iron overload disorder in pregnancy • Pharmacokinetics of Iron overload disorder •
Genetics, Pharmacogenomics, and Proteinomics of Iron overload disorder	Genetics of Iron overload disorder • Pharmacogenomics of Iron overload disorder • Proteomics of Iron overload disorder
Newstories on Iron overload disorder	Iron overload disorder in the news • Be alerted to news on Iron overload disorder • News trends on Iron overload disorder
Commentary on Iron overload disorder	Blogs on Iron overload disorder
Patient Resources on Iron overload disorder	Patient resources on Iron overload disorder • Discussion groups on Iron overload disorder • Patient Handouts on Iron overload disorder • Directions to Hospitals Treating Iron overload disorder • Risk calculators and risk factors for Iron overload disorder
Healthcare Provider Resources on Iron overload disorder	Symptoms of Iron overload disorder • Causes & Risk Factors for Iron overload disorder • Diagnostic studies for Iron overload disorder • Treatment of Iron overload disorder
Continuing Medical Education (CME) Programs on Iron overload disorder	CME Programs on Iron overload disorder
International Resources on Iron overload disorder	Iron overload disorder en Espanol • Iron overload disorder en Francais
Business Resources on Iron overload disorder	Iron overload disorder in the Marketplace • Patents on Iron overload disorder
Informatics Resources on Iron overload disorder	List of terms related to Iron overload disorder

v • d • e Abnormal clinical and laboratory findings (R70-R94, 790-796)
Blood test	Red blood cells Elevated ESR - Anisocytosis - Poikilocytosis - Reticulocytosis - Inclusion bodies (Howell-Jolly body, Heinz body) Small molecules blood sugar: Abnormal glucose tolerance test - Hyperglycemia - Impaired glucose tolerance - Prediabetes other small molecules: Azotemia - Hyperuricemia Enzymes/other proteins Elevated transaminases - Cardiac marker - Elevated alpha-fetoprotein Minerals Iron overload disorder Pathogens/sepsis Bacteremia - Viremia - Fungemia - Parasitemia
Urine test	Proteinuria Albuminuria/Microalbuminuria - Myoglobinuria - Hemoglobinuria Small molecules Glycosuria - Ketonuria - Bilirubinuria Red blood cells Hematuria Other Chyluria - Crystalluria
Other	Abnormal basal metabolic rate - Latent tuberculosis

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .