SLC5A1

Solute carrier family 5 (sodium/glucose cotransporter), member 1
Identifiers
Symbol(s)	SLC5A1; D22S675; NAGT; SGLT1
External IDs	OMIM: 182380 MGI: 107678 Homologene: 55456
Gene ontology Molecular Function: • transporter activity • sugar:hydrogen ion symporter activity • glucose:sodium symporter activity • symporter activity • sodium ion binding Cellular Component: • integral to plasma membrane • brush border • membrane • apical plasma membrane Biological Process: • metanephros development • ion transport • sodium ion transport • glucose transport • intestinal absorption
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6523	20537
Ensembl	ENSG00000100170	ENSMUSG00000011034
Uniprot	P13866	O70122
Refseq	NM_000343 (mRNA) NP_000334 (protein)	NM_019810 (mRNA) NP_062784 (protein)
Location	Chr 22: 30.77 - 30.84 Mb	Chr 5: 33.42 - 33.48 Mb
Pubmed search	[1]	[2]

Solute carrier family 5 (sodium/glucose cotransporter), member 1, also known as SLC5A1, is a human gene.

Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.[supplied by OMIM]

See also

• Sodium-glucose transport proteins
• Solute carrier family

Further reading

• Wright EM, Loo DD, Panayotova-Heiermann M, et al. (1995). "'Active' sugar transport in eukaryotes.". J. Exp. Biol. 196: 197-212. PMID 7823022.
• Wright EM, Turk E, Martin MG (2003). "Molecular basis for glucose-galactose malabsorption.". Cell Biochem. Biophys. 36 (2-3): 115-21. PMID 12139397.
• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845-67. PMID 12488461.
• Turk E, Zabel B, Mundlos S, et al. (1991). "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter.". Nature 350 (6316): 354-6. doi:10.1038/350354a0. PMID 2008213.
• Hediger MA, Turk E, Wright EM (1989). "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5748-52. PMID 2490366.
• Delézay O, Baghdiguian S, Fantini J (1995). "The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C.". J. Biol. Chem. 270 (21): 12536-41. PMID 7759499.
• Turk E, Martín MG, Wright EM (1994). "Structure of the human Na+/glucose cotransporter gene SGLT1.". J. Biol. Chem. 269 (21): 15204-9. PMID 8195156.
• Turk E, Klisak I, Bacallao R, et al. (1993). "Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1.". Genomics 17 (3): 752-4. doi:10.1006/geno.1993.1399. PMID 8244393.
• Martín MG, Turk E, Lostao MP, et al. (1996). "Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption.". Nat. Genet. 12 (2): 216-20. doi:10.1038/ng0296-216. PMID 8563765.
• Turk E, Kerner CJ, Lostao MP, Wright EM (1996). "Membrane topology of the human Na+/glucose cotransporter SGLT1.". J. Biol. Chem. 271 (4): 1925-34. PMID 8567640.
• Lam JT, Martín MG, Turk E, et al. (1999). "Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects.". Biochim. Biophys. Acta 1453 (2): 297-303. PMID 10036327.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
• Obermeier S, Hüselweh B, Tinel H, et al. (2001). "Expression of glucose transporters in lactating human mammary gland epithelial cells.". European journal of nutrition 39 (5): 194-200. PMID 11131365.
• Kasahara M, Maeda M, Hayashi S, et al. (2001). "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein.". Biochim. Biophys. Acta 1536 (2-3): 141-7. PMID 11406349.
• Roll P, Massacrier A, Pereira S, et al. (2002). "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families.". Gene 285 (1-2): 141-8. PMID 12039040.
• Ikari A, Nakano M, Kawano K, Suketa Y (2002). "Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70.". J. Biol. Chem. 277 (36): 33338-43. doi:10.1074/jbc.M200310200. PMID 12082088.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.