Lactoferrin
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| Lactoferrin
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| Identifiers | |
| Symbol | LF |
| Entrez | 4057 |
| HUGO | 6720 |
| OMIM | 150210 |
| RefSeq | NM_002343 |
| UniProt | P02788 |
| Other data | |
| Locus | Chr. 3 q21-23 |
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Lactoferrin (LF), a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Human colostrum has the highest concentration, followed by human milk, then cow milk.
Structure
Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa).
Function
Lactoferrin antimicrobial activity is due partly to its high affinity for Fe (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.
Lactoferrin receptors have been found on brush-border cells, PMN, monocytes, Mφ and activated lymphocytes.
Genetics
Genetically modified (transgenic) rice LL601 (Liberty Link 601) produces this protein.
External links
- Thompson.net Supported information about lactoferrin.
- FDA Lactoferrin Considered Safe to Fight E. Coli.
- lactoferrinresearch.org
- Agennix.com A biopharmaceutical company focused on developing protein-based drugs for cancer and diabetic ulcers.
- Pharming.com A biopharmaceutical company producing lactoferrin.
Proteins: globulins | |
|---|---|
| Serum | Alpha globulins - Beta globulins - Gamma globulin (Immunoglobulins) - Fibronectins - Macroglobulins - Transcobalamins |
| Other | Beta-lactoglobulin (Lactoferrin) - Thyroglobulin - Alpha-lactalbumin |
Carrier proteins, metalloproteins: iron-binding proteins | |
|---|---|
| heme | Ferritin (Bacterioferritin) - Lactoferrin - Transferrin |
| nonheme | Hemerythrin - Inositol oxygenase - Iron-sulfur protein - Lipoxygenase - Tyrosine hydroxylase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
