SLC9A5

Solute carrier family 9 (sodium/hydrogen exchanger), member 5
Identifiers
Symbol(s)	SLC9A5; NHE5
External IDs	OMIM: 600477 MGI: 2685542 Homologene: 31247
Gene ontology Molecular Function: • antiporter activity • solute:hydrogen antiporter activity • sodium:hydrogen antiporter activity • sodium ion binding Cellular Component: • membrane • integral to membrane Biological Process: • ion transport • sodium ion transport • regulation of pH
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6553	277973
Ensembl	ENSG00000135740	ENSMUSG00000014786
Uniprot	Q14940	na
Refseq	NM_004594 (mRNA) NP_004585 (protein)	XM_894890 (mRNA) XP_899983 (protein)
Location	Chr 16: 65.84 - 65.86 Mb	Chr 8: 108.24 - 108.26 Mb
Pubmed search	[1]	[2]

Solute carrier family 9 (sodium/hydrogen exchanger), member 5, also known as SLC9A5, is a human gene.

See also

• Solute carrier family

Further reading

• Klanke CA, Su YR, Callen DF, et al. (1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1.". Genomics 25 (3): 615-22. PMID 7759094.
• Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain.". J. Biol. Chem. 274 (7): 4377-82. PMID 9933641.
• Attaphitaya S, Park K, Melvin JE (1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain.". J. Biol. Chem. 274 (7): 4383-8. PMID 9933642.
• Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.". J. Biol. Chem. 277 (45): 42623-32. doi:10.1074/jbc.M206629200. PMID 12205089.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443-9. PMID 12417987.
• Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.". Biol. Pharm. Bull. 26 (2): 148-55. PMID 12576672.
• Lin WM, Chen XH, Xu R, et al.. "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao : [Acta physiologica Sinica] 55 (1): 79-82. PMID 12598940.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790-5. doi:10.1073/pnas.0407444102. PMID 15699339.
• Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.". Cell. Signal. 19 (1): 194-203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.