Lipoprotein
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Overview
A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins. Many enzymes, transporters, structural proteins, antigens, adhesins and toxins are lipoproteins. Examples include the high density and low density lipoproteins of the blood, the transmembrane proteins of the mitochondrion and the chloroplast, and bacterial lipoproteins [2].
Function
The lipids are often an essential part of the complex, even if they seem to have no catalytic activity themselves. To isolate transmembrane lipoproteins from their associated membranes, detergents are often needed.
All cells use and rely on fats and, for all animal cells, cholesterol as building blocks to create the multiple membranes which cells use to both control internal water content, internal water soluble elements and to organize their internal structure and protein enzymatic systems.
Lipoproteins in the blood, a water medium, carry fats around the body. The protein particles have charged groups aimed outward so as to attract water molecules; this makes them soluble in the salt water based blood pool. Triglyceride-fats and cholesterol are carried internally, shielded by the protein particle from the water.
The interaction of the proteins forming the surface of the particles with (a) enzymes in the blood, (b) with each other and (c) with specific proteins on the surfaces of cells determine whether triglycerides and cholesterol will be added to or removed from the lipoprotein transport particles.
Regarding atheroma development and progression vs. regression, the key issue has always been cholesterol transport patterns, not cholesterol concentration itself.
Classification
By density
General categories of lipoproteins, listed in order from larger and less dense (more fat than protein) to smaller and more dense (more protein, less fat):
- Chylomicrons - carry triacylglycerol (fat) from the intestines to the liver and to adipose tissue.
- Very low density lipoproteins - carry (newly synthesised) triacylglycerol from the liver to adipose tissue.
- Intermediate density lipoproteins - are intermediate between VLDL and LDL. They are not usually detectable in the blood.
- Low density lipoproteins - carry cholesterol from the liver to cells of the body. Sometimes referred to as the "bad cholesterol" lipoprotein.
- High density lipoproteins - collects cholesterol from the body's tissues, and brings it back to the liver. Sometimes referred to as the "good cholesterol" lipoprotein.
Alpha and beta
It is also possible to classify lipoproteins as "alpha" and "beta", akin to the classification of proteins in serum protein electrophoresis. This terminolgy is sometimes used in describing lipid disorders such as Abetalipoproteinemia.
Lipoprotein(a)
Lipoprotein(a) - Lp(a), Cardiology diagnostic tests
- Normal: <14mg/dL
- High risk: >19mg/dL
source: Beyond Cholesterol, Julius Torelli MD, 2005 ISBN 0-312-34863-0 p.91
See also
External links
- Database of bacterial lipoproteins at mrc-lmb.cam.ac.uk
- Overview and diagram at washington.edu
- Lipoprotein assembly at wisc.edu
- Lipoprotein circulation at purdue.edu
- MeSH Lipoproteins
- MeSH Proteolipids
Lipids: membrane lipids |
|---|
Lipid bilayer - Phospholipids - Proteolipids - Sphingolipids - Sterols |
Lipids: lipoprotein metabolism | |
|---|---|
| General | Chylomicron - HDL - LDL - IDL - VLDL - Lp(a) |
| Apolipoproteins | APOA (1, 2, 5) - APOB - APOC (1, 2, 3, 4) - APOD - APOE - APOH |
| Other | Lipoprotein lipase - HDL (Cholesterylester transfer proteinAcetyl-CoA C-acyltransferase, LCAT) - LDL receptor - Microsomal triglyceride transfer protein - ABCA1 - Lecithin-cholesterol acyltransferase |
| see also disorders | |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
