Relaxin receptor
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| relaxin/insulin-like family peptide receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | RXFP1 |
| Alt. symbols | LGR7 |
| Entrez | 59350 |
| HUGO | 19718 |
| OMIM | 606654 |
| RefSeq | NM_021634 |
| UniProt | Q9HBX9 |
| Other data | |
| Locus | Chr. 4 q31.3 |
| relaxin/insulin-like family peptide receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | RXFP2 |
| Alt. symbols | LGR8, GREAT, GPR106, INSL3R |
| Entrez | 122042 |
| HUGO | 17318 |
| OMIM | 606655 |
| RefSeq | NM_130806 |
| UniProt | Q8WXD0 |
| Other data | |
| Locus | Chr. 13 q12.3 |
| relaxin/insulin-like family peptide receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | RXFP3 |
| Alt. symbols | RLN3R1, SALPR, GPCR135 |
| Entrez | 51289 |
| HUGO | 24883 |
| OMIM | 609445 |
| RefSeq | NM_016568 |
| UniProt | Q9NSD7 |
| Other data | |
| Locus | Chr. 5 p15.1-p14 |
| relaxin/insulin-like family peptide receptor 4 | |
|---|---|
| Identifiers | |
| Symbol | RXFP4 |
| Alt. symbols | GPR100, GPCR142, RLN3R2 |
| Entrez | 339403 |
| HUGO | 14666 |
| OMIM | 609043 |
| RefSeq | NM_181885 |
| UniProt | Q8TDU9 |
| Other data | |
| Locus | Chr. 1 q22 |
The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
| RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
| RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
| RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
See also
- Relaxin family peptide hormones
- Insulin/IGF/Relaxin family
- Relaxin/insulin-like family peptide receptor 1
References
- ↑ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
- ↑ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.
External links
- "Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- relaxin+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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