Neuropeptide Y receptor Y2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Neuropeptide Y receptor type 2 (Y2R)''' is a [[protein]] that in humans is encoded by the ''NPY2R'' [[gene]].<ref name="pmid7559383">{{cite journal | vauthors = Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R | title = Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 39 | pages = 22661–4 | date = Sep 1995 | pmid = 7559383 | pmc =  | doi = 10.1074/jbc.270.39.22661 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPY2R neuropeptide Y receptor Y2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4887| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Selective ligands ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Neuropeptide Y receptor Y2
| HGNCid = 7957
| Symbol = NPY2R
| AltSymbols =;
| OMIM = 162642
| ECnumber = 
| Homologene = 701
| MGIid = 108418
| GeneAtlas_image1 = PBB_GE_NPY2R_210730_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NPY2R_210729_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001601 |text = peptide YY receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005246 |text = calcium channel regulator activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4887
    | Hs_Ensembl = ENSG00000185149
    | Hs_RefseqProtein = NP_000901
    | Hs_RefseqmRNA = NM_000910
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 156349231
    | Hs_GenLoc_end = 156357677
    | Hs_Uniprot = P49146
    | Mm_EntrezGene = 18167
    | Mm_Ensembl = ENSMUSG00000028004
    | Mm_RefseqmRNA = NM_008731
    | Mm_RefseqProtein = NP_032757
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 82624310
    | Mm_GenLoc_end = 82634013
    | Mm_Uniprot = Q8BWV1
  }}
}}
'''Neuropeptide Y receptor Y2''', also known as '''NPY2R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPY2R neuropeptide Y receptor Y2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4887| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
=== Agonists ===
{{PBB_Summary
* [[Neuropeptide Y]] (endogenous agonist, non subtype selective)
| section_title =  
* Neuropeptide Y fragment 13-36 (NPY<sub>2</sub> selective agonist)
| summary_text =  
* 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
}}
* [[Peptide YY]]
* Peptide YY 3-36 fragment<ref name="pmid17077190">{{cite journal | vauthors = Murphy KG, Dhillo WS, Bloom SR | title = Gut peptides in the regulation of food intake and energy homeostasis | journal = Endocrine Reviews | volume = 27 | issue = 7 | pages = 719–27 | date = Dec 2006 | pmid = 17077190 | doi = 10.1210/er.2006-0028 }}</ref>


==See also==
=== Antagonists ===
* [[BIIE-0246]] (CAS# 246146-55-4)
* JNJ 5207787 (CAS# 683746-68-1)
* SF 11 (CAS# 443292-81-7)
 
== See also ==
* [[Neuropeptide Y receptor]]
* [[Neuropeptide Y receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2368 | title = Neuropeptide Y Receptors: Y<sub>2</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wan CP, Lau BH | title = Neuropeptide Y receptor subtypes | journal = Life Sciences | volume = 56 | issue = 13 | pages = 1055–64 | date = Feb 1995 | pmid = 9001438 | doi = 10.1016/0024-3205(95)00041-4 }}
| citations =
* {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = Apr 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
*{{cite journal | author=Wan CP, Lau BH |title=Neuropeptide Y receptor subtypes. |journal=Life Sci. |volume=56 |issue= 13 |pages= 1055-64 |year= 1997 |pmid= 9001438 |doi= }}
* {{cite journal | vauthors = Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA | title = Cloned human neuropeptide Y receptor couples to two different second messenger systems | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 13 | pages = 5794–8 | date = Jul 1992 | pmid = 1321422 | pmc = 402104 | doi = 10.1073/pnas.89.13.5794 }}
*{{cite journal | author=Parker E, Van Heek M, Stamford A |title=Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. |journal=Eur. J. Pharmacol. |volume=440 |issue= 2-3 |pages= 173-87 |year= 2002 |pmid= 12007534 |doi= }}
* {{cite journal | vauthors = Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL | title = Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype | journal = The Journal of Biological Chemistry | volume = 270 | issue = 45 | pages = 26758–61 | date = Nov 1995 | pmid = 7592910 | doi = 10.1074/jbc.270.45.26758 }}
*{{cite journal | author=Herzog H, Hort YJ, Ball HJ, ''et al.'' |title=Cloned human neuropeptide Y receptor couples to two different second messenger systems. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5794-8 |year= 1992 |pmid= 1321422 |doi=  }}
* {{cite journal | vauthors = Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K | title = A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line | journal = The Journal of Biological Chemistry | volume = 269 | issue = 11 | pages = 8226–33 | date = Mar 1994 | pmid = 8132547 | doi =  }}
*{{cite journal  | author=Rose PM, Fernandes P, Lynch JS, ''et al.'' |title=Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 22661-4 |year= 1995 |pmid= 7559383 |doi=  }}
* {{cite journal | vauthors = Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA | title = Expression cloning of a human brain neuropeptide Y Y2 receptor | journal = Molecular Pharmacology | volume = 49 | issue = 2 | pages = 224–8 | date = Feb 1996 | pmid = 8632753 | doi =  }}
*{{cite journal | author=Gerald C, Walker MW, Vaysse PJ, ''et al.'' |title=Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26758-61 |year= 1995 |pmid= 7592910 |doi= }}
* {{cite journal | vauthors = Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W | title = Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 4661–5 | date = May 1996 | pmid = 8643460 | pmc = 39335 | doi = 10.1073/pnas.93.10.4661 }}
*{{cite journal | author=Lynch JW, Lemos VS, Bucher B, ''et al.'' |title=A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line. |journal=J. Biol. Chem. |volume=269 |issue= 11 |pages= 8226-33 |year= 1994 |pmid= 8132547 |doi=  }}
* {{cite journal | vauthors = Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA | title = Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene | journal = Genomics | volume = 38 | issue = 3 | pages = 392–8 | date = Dec 1996 | pmid = 8975716 | doi = 10.1006/geno.1996.0642 | last5 = Kolakowski }}
*{{cite journal | author=Gehlert DR, Beavers LS, Johnson D, ''et al.'' |title=Expression cloning of a human brain neuropeptide Y Y2 receptor. |journal=Mol. Pharmacol. |volume=49 |issue= 2 |pages= 224-8 |year= 1996 |pmid= 8632753 |doi=  }}
* {{cite journal | vauthors = Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = The Journal of Biological Chemistry | volume = 273 | issue = 28 | pages = 17749–55 | date = Jul 1998 | pmid = 9651375 | doi = 10.1074/jbc.273.28.17749 }}
*{{cite journal | author=Yan H, Yang J, Marasco J, ''et al.'' |title=Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4661-5 |year= 1996 |pmid= 8643460 |doi= }}
* {{cite journal | vauthors = Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL | title = Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain | journal = Neuroscience | volume = 86 | issue = 1 | pages = 167–78 | date = Sep 1998 | pmid = 9692752 | doi = 10.1016/S0306-4522(98)00039-6 }}
*{{cite journal | author=Ammar DA, Eadie DM, Wong DJ, ''et al.'' |title=Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. |journal=Genomics |volume=38 |issue= 3 |pages= 392-8 |year= 1997 |pmid= 8975716 |doi= }}
* {{cite journal | vauthors = Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M | title = The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning | journal = Molecular Pharmacology | volume = 60 | issue = 1 | pages = 124–34 | date = Jul 2001 | pmid = 11408607 | doi =  }}
*{{cite journal | author=Snow BE, Hall RA, Krumins AM, ''et al.'' |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749-55 |year= 1998 |pmid= 9651375 |doi= }}
* {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = Mar 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
*{{cite journal | author=Caberlotto L, Fuxe K, Rimland JM, ''et al.'' |title=Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain. |journal=Neuroscience |volume=86 |issue= 1 |pages= 167-78 |year= 1998 |pmid= 9692752 |doi= }}
* {{cite journal | vauthors = Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L | title = Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues | journal = Peptides | volume = 23 | issue = 5 | pages = 927–34 | date = May 2002 | pmid = 12084524 | doi = 10.1016/S0196-9781(02)00003-7 }}
*{{cite journal | author=Goumain M, Voisin T, Lorinet AM, ''et al.'' |title=The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. |journal=Mol. Pharmacol. |volume=60 |issue= 1 |pages= 124-34 |year= 2001 |pmid= 11408607 |doi=  }}
* {{cite journal | vauthors = Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM | title = Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues | journal = British Journal of Pharmacology | volume = 139 | issue = 4 | pages = 863–71 | date = Jun 2003 | pmid = 12813010 | pmc = 1573894 | doi = 10.1038/sj.bjp.0705298 }}
*{{cite journal | author=Cox HM, Tough IR |title=Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1505-12 |year= 2002 |pmid= 11906964 |doi= 10.1038/sj.bjp.0704604 }}
* {{cite journal | vauthors = Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS | title = Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits | journal = Diabetes | volume = 53 | issue = 9 | pages = 2461–6 | date = Sep 2004 | pmid = 15331560 | doi = 10.2337/diabetes.53.9.2461 }}
*{{cite journal | author=Uddman R, Möller S, Nilsson T, ''et al.'' |title=Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. |journal=Peptides |volume=23 |issue= 5 |pages= 927-34 |year= 2003 |pmid= 12084524 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Hyland NP, Sjöberg F, Tough IR, ''et al.'' |title=Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues. |journal=Br. J. Pharmacol. |volume=139 |issue= 4 |pages= 863-71 |year= 2004 |pmid= 12813010 |doi= 10.1038/sj.bjp.0705298 }}
*{{cite journal | author=Hung CC, Pirie F, Luan J, ''et al.'' |title=Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. |journal=Diabetes |volume=53 |issue= 9 |pages= 2461-6 |year= 2004 |pmid= 15331560 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{transmembranereceptor-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g1}}
{{Neuropeptidergics}}
 
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}

Revision as of 00:57, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuropeptide Y receptor type 2 (Y2R) is a protein that in humans is encoded by the NPY2R gene.[1][2]

Selective ligands

Agonists

  • Neuropeptide Y (endogenous agonist, non subtype selective)
  • Neuropeptide Y fragment 13-36 (NPY2 selective agonist)
  • 2-Thiouridine 5'-triphosphate (CAS# 35763-29-2)
  • Peptide YY
  • Peptide YY 3-36 fragment[3]

Antagonists

  • BIIE-0246 (CAS# 246146-55-4)
  • JNJ 5207787 (CAS# 683746-68-1)
  • SF 11 (CAS# 443292-81-7)

See also

References

  1. ↑ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
  2. ↑ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".
  3. ↑ Murphy KG, Dhillo WS, Bloom SR (Dec 2006). "Gut peptides in the regulation of food intake and energy homeostasis". Endocrine Reviews. 27 (7): 719–27. doi:10.1210/er.2006-0028. PMID 17077190.

External links

Further reading

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