Jump to navigation Jump to search
Clinical data
ATC code
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass163.259 g/mol

WikiDoc Resources for Mephentermine


Most recent articles on Mephentermine

Most cited articles on Mephentermine

Review articles on Mephentermine

Articles on Mephentermine in N Eng J Med, Lancet, BMJ


Powerpoint slides on Mephentermine

Images of Mephentermine

Photos of Mephentermine

Podcasts & MP3s on Mephentermine

Videos on Mephentermine

Evidence Based Medicine

Cochrane Collaboration on Mephentermine

Bandolier on Mephentermine

TRIP on Mephentermine

Clinical Trials

Ongoing Trials on Mephentermine at Clinical

Trial results on Mephentermine

Clinical Trials on Mephentermine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mephentermine

NICE Guidance on Mephentermine


FDA on Mephentermine

CDC on Mephentermine


Books on Mephentermine


Mephentermine in the news

Be alerted to news on Mephentermine

News trends on Mephentermine


Blogs on Mephentermine


Definitions of Mephentermine

Patient Resources / Community

Patient resources on Mephentermine

Discussion groups on Mephentermine

Patient Handouts on Mephentermine

Directions to Hospitals Treating Mephentermine

Risk calculators and risk factors for Mephentermine

Healthcare Provider Resources

Symptoms of Mephentermine

Causes & Risk Factors for Mephentermine

Diagnostic studies for Mephentermine

Treatment of Mephentermine

Continuing Medical Education (CME)

CME Programs on Mephentermine


Mephentermine en Espanol

Mephentermine en Francais


Mephentermine in the Marketplace

Patents on Mephentermine

Experimental / Informatics

List of terms related to Mephentermine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Mephentermine is a cardiac stimulant. It was formerly used in Wyamine nasal decongestant inhalers and before that as a stimulant in psychiatry.

It has been used as a treatment for low blood pressure.[1]

ATC Classification: C01CA11 - mephentermine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.

Mechanism of Action

Mephentermine appears to act by indirect stimulation of β-adrenergic receptors causing the release of norepinephrine from its storage sites. It has a positive inotropic effect on the myocardium. AV conduction and refractory period of AV node is shortened with an increase in ventricular conduction velocity. It dilates arteries and arterioles in the skeletal muscle and mesenteric vascular beds, leading to an increase in venous return.

Onset: 5-15 minutes (IM), immediate (IV).

Duration: 4 hr (IM), 30 minutes (IV).

Indication & Dosage

Maintenance of blood pressure in hypotensive states Adult: 30-45 mg as a single dose, repeated as necessary or followed by IV infusion of 0.1% mephentermine in 5% dextrose, rate and duration of administration will depend on patient's response.

Hypotension secondary to spinal anaesthesia in obstetric patients Adult: 15 mg as a single dose, repeat if needed.



Low blood pressure caused by phenothiazines. Hypertension. Pheochromocytoma.

Special Precautions

Patient on MAOIs. For shock due to loss of blood or fluid, give fluid replacement therapy primarily, CVS disease, hypertension, hyperthyroidism, chronic illnesses, lactation, pregnancy.

Adverse Drug Reactions

Drowsiness, incoherence, hallucinations, convulsions, fast heart rate. Fear, anxiety, restlessness, tremor, insomnia, confusion, irritability, and psychosis. Nausea, vomiting, reduced appetite, urinary retention, dyspnea, weakness.

Potentially Fatal: AV block, CNS stimulation. Cerebral hemorrhage and pulmonary edema, ventricular arrhythmias.

Drug Interactions

Antagonizes effect of agents that lower blood pressure. Severe hypertension with MAOIs and possibly tricyclic antidepressants. Additive vasoconstricting effects with ergot alkaloids, oxytocin.

Potentially Fatal: Risk of abnormal heart rhythm in people undergoing anesthesia with cyclopropane and halothane.


  1. WHITTINGTON RM (May 1963). "Mephentemine Sulphate as a Hypertensive Agent in General Practice". J Coll Gen Pract. 6 (2): 336–7. PMC 1878111. PMID 14000433.

Template:Cardiac stimulants excluding cardiac glycosides