Indoramin

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{{Drugbox | Verifiedfields = changed | verifiedrevid = 461936008 | IUPAC_name = N-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}benzamide | image = Indoramin_svg.png

| tradename = | Drugs.com = International Drug Names | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref =  ☒N | CAS_number = 26844-12-2 | ATC_prefix = C02 | ATC_suffix = CA02 | PubChem = 33625 | IUPHAR_ligand = 501 | DrugBank_Ref =  ☑Y | DrugBank = | ChemSpiderID_Ref =  ☑Y | ChemSpiderID = 31014 | UNII_Ref =  ☑Y | UNII = 0Z802HMY7H | KEGG_Ref =  ☑Y | KEGG = D04531 | ChEMBL_Ref =  ☑Y | ChEMBL = 279516

| C=22 | H=25 | N=3 | O=1 | molecular_weight = 347.454 g/mol | smiles = O=C(c1ccccc1)NC4CCN(CCc3c2ccccc2nc3)CC4 | InChI = 1/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26) | InChIKey = JXZZEXZZKAWDSP-UHFFFAOYAC | StdInChI_Ref =  ☑Y | StdInChI = 1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26) | StdInChIKey_Ref =  ☑Y | StdInChIKey = JXZZEXZZKAWDSP-UHFFFAOYSA-N }}

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Indoramin (trade names Baratol and Doralese) is a piperidine antiadrenergic agent.

It is an alpha-1 selective adrenoceptor antagonist[1] with direct myocardial depression action; therefore, it results in no reflex tachycardia. It is also used in benign prostatic hyperplasia (BPH).[2]

It is commonly synthesized from tryptophol.[3]

Dosage

Indoramin is commonly prescribed as 20mg tablets when used in BPH.[4]

Side Effects

Drowsiness, dizziness, dry mouth, nasal congestion, headache, fatigue, weight gain, hypotension, postural hypotension, depression, problems with ejaculation, diarrhoea, nausea, increased need to pass urine, and palpitations.[5]

References

  1. Pierce V, Shepperson NB, Todd MH, Waterfall JF (February 1986). "Investigation into the cardioregulatory properties of the alpha 1-adrenoceptor blocker indoramin". Br. J. Pharmacol. 87 (2): 433–441. doi:10.1111/j.1476-5381.1986.tb10834.x. PMC 1916533. PMID 3955309.
  2. "Indoramin 20mg tablets". Medicines.org.uk. April 20, 2011. Retrieved September 30, 2012.
  3. Ullman's encyclopedia of Industrial Chemistry, Sixth Edition, 2002.
  4. "Indoramin hydrochloride". National Health Service (UK). Retrieved September 30, 2012.
  5. "Indoramin 20mg tablets". Medicines.org.uk. Retrieved September 30, 2012.

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