Orciprenaline

Jump to: navigation, search
Orciprenaline
Orciprenaline skeletal.png
Orciprenaline ball-and-stick.png
Clinical data
AHFS/Drugs.commonograph
MedlinePlusa682084
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration
Inhalation / tablets
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability3% if inhaled, 40% if taken orally
MetabolismGastrointestinal and hepatic
Elimination half-life6 hours
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC11H17NO3
Molar mass211.258 g/mol
3D model (JSmol)
Solubility in water9.7 mg/mL (20 °C)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Orciprenaline

Articles

Most recent articles on Orciprenaline

Most cited articles on Orciprenaline

Review articles on Orciprenaline

Articles on Orciprenaline in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Orciprenaline

Images of Orciprenaline

Photos of Orciprenaline

Podcasts & MP3s on Orciprenaline

Videos on Orciprenaline

Evidence Based Medicine

Cochrane Collaboration on Orciprenaline

Bandolier on Orciprenaline

TRIP on Orciprenaline

Clinical Trials

Ongoing Trials on Orciprenaline at Clinical Trials.gov

Trial results on Orciprenaline

Clinical Trials on Orciprenaline at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Orciprenaline

NICE Guidance on Orciprenaline

NHS PRODIGY Guidance

FDA on Orciprenaline

CDC on Orciprenaline

Books

Books on Orciprenaline

News

Orciprenaline in the news

Be alerted to news on Orciprenaline

News trends on Orciprenaline

Commentary

Blogs on Orciprenaline

Definitions

Definitions of Orciprenaline

Patient Resources / Community

Patient resources on Orciprenaline

Discussion groups on Orciprenaline

Patient Handouts on Orciprenaline

Directions to Hospitals Treating Orciprenaline

Risk calculators and risk factors for Orciprenaline

Healthcare Provider Resources

Symptoms of Orciprenaline

Causes & Risk Factors for Orciprenaline

Diagnostic studies for Orciprenaline

Treatment of Orciprenaline

Continuing Medical Education (CME)

CME Programs on Orciprenaline

International

Orciprenaline en Espanol

Orciprenaline en Francais

Business

Orciprenaline in the Marketplace

Patents on Orciprenaline

Experimental / Informatics

List of terms related to Orciprenaline

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Orciprenaline (INN, also known as metaproterenol) is a bronchodilator used in the treatment of asthma.[1][2] Orciprenaline is a moderately selective beta2-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.

Possible side effects

  • tremor
  • nervousness
  • dizziness
  • weakness
  • headache
  • nausea
  • tachycardia
Rare side effects that could be life-threatening
  • increased difficulty breathing
  • rapid or increased heart rate
  • irregular heartbeat
  • chest pain or discomfort

Brand names

  • Alupent
  • Metaprel

References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. doi:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
  2. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic Acids Res. 36 (Database issue): D901–6. doi:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.

Linked-in.jpg