CCR4
| Chemokine (C-C motif) receptor 4 | |||||||||||
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| Symbols | CCR4 ; CC-CKR-4; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5; MGC88293; k5-5, ChemR13, CD194 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21135 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Chemokine (C-C motif) receptor 4, also known as CCR4, is a human gene.[1]
CCR4 has also recently been designated CD194 (cluster of differentiation 194).
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.[1]
References
Further reading
- Yoshie O (2005). "Expression of CCR4 in adult T-cell leukemia". Leuk. Lymphoma. 46 (2): 185–90. doi:10.1080/10428190400007607. PMID 15621800.
- Power CA, Meyer A, Nemeth K; et al. (1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J. Biol. Chem. 270 (33): 19495–500. PMID 7642634.
- Hoogewerf A, Black D, Proudfoot AE; et al. (1996). "Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4". Biochem. Biophys. Res. Commun. 218 (1): 337–43. PMID 8573157.
- Samson M, Soularue P, Vassart G, Parmentier M (1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.
- Imai T, Baba M, Nishimura M; et al. (1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. PMID 9169480.
- Imai T, Chantry D, Raport CJ; et al. (1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. PMID 9430724.
- Struyf S, Proost P, Sozzani S; et al. (1998). "Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor". J. Immunol. 161 (6): 2672–5. PMID 9743322.
- Proost P, Struyf S, Schols D; et al. (1999). "Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction". J. Biol. Chem. 274 (7): 3988–93. PMID 9933589.
- Marchese A, Sawzdargo M, Nguyen T; et al. (1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
- Campbell JJ, Haraldsen G, Pan J; et al. (1999). "The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells". Nature. 400 (6746): 776–80. doi:10.1038/23495. PMID 10466728.
- Inngjerdingen M, Damaj B, Maghazachi AA (2000). "Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309". J. Immunol. 164 (8): 4048–54. PMID 10754297.
- Kato H, Tsuchiya N, Izumi S; et al. (2001). "New variations of human CC-chemokine receptors CCR3 and CCR4". Genes Immun. 1 (2): 97–104. doi:10.1038/sj.gene.6363638. PMID 11196669.
- Yoshie O, Fujisawa R, Nakayama T; et al. (2002). "Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells". Blood. 99 (5): 1505–11. PMID 11861261.
- Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001.
- Juremalm M, Olsson N, Nilsson G (2002). "Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4". Biochem. Biophys. Res. Commun. 297 (3): 480–5. PMID 12270118.
- Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking". Blood. 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880.
- Agrawal L, Vanhorn-Ali Z, Alkhatib G (2002). "Multiple determinants are involved in HIV coreceptor use as demonstrated by CCR4/CCL22 interaction in peripheral blood mononuclear cells (PBMCs)". J. Leukoc. Biol. 72 (5): 1063–74. PMID 12429730.
- Uchida T, Suto H, Ra C; et al. (2003). "Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis". Int. Immunol. 14 (12): 1431–8. PMID 12456591.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ferenczi K, Fuhlbrigge RC, Pinkus J; et al. (2003). "Increased CCR4 expression in cutaneous T cell lymphoma". J. Invest. Dermatol. 119 (6): 1405–10. doi:10.1046/j.1523-1747.2002.19610.x. PMID 12485447.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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