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{{Infobox_gene}}
{{Infobox_gene}}
'''Macrophage scavenger receptor 1''', also known as '''MSR1''', is a [[protein]] which in humans is encoded by the ''MSR1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MSR1 macrophage scavenger receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4481| accessdate = }}</ref><ref name="pmid2251254">{{cite journal |vauthors=Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H | title = Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 23 | pages = 9133–7 |date=December 1990 | pmid = 2251254 | pmc = 55118 | doi = 10.1073/pnas.87.23.9133| url = | issn = }}</ref>
'''Macrophage scavenger receptor 1''', also known as '''MSR1''', is a [[protein]] which in humans is encoded by the ''MSR1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MSR1 macrophage scavenger receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4481| accessdate = }}</ref><ref name="pmid2251254">{{cite journal |vauthors=Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H | title = Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 23 | pages = 9133–7 |date=December 1990 | pmid = 2251254 | pmc = 55118 | doi = 10.1073/pnas.87.23.9133| url = | issn = | bibcode = 1990PNAS...87.9133M }}</ref>


MSR1 has also recently been designated '''CD204''' ([[cluster of differentiation]] 204).
MSR1 has also recently been designated '''CD204''' ([[cluster of differentiation]] 204).
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*{{cite journal  |vauthors=Asaoka H, Matsumoto A, Itakura H, Kodama T |title=[Structural and function of the human macrophage scavenger receptor] |journal=Nippon Rinsho |volume=51 |issue= 6 |pages= 1677–83 |year= 1993 |pmid= 8391600 |doi=  }}
*{{cite journal  |vauthors=Asaoka H, Matsumoto A, Itakura H, Kodama T |title=[Structural and function of the human macrophage scavenger receptor] |journal=Nippon Rinsho |volume=51 |issue= 6 |pages= 1677–83 |year= 1993 |pmid= 8391600 |doi=  }}
*{{cite journal  |vauthors=Naito M, Suzuki H, Mori T, etal |title=Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions. |journal=Am. J. Pathol. |volume=141 |issue= 3 |pages= 591–9 |year= 1992 |pmid= 1519666 |doi=  | pmc=1886699  }}
*{{cite journal  |vauthors=Naito M, Suzuki H, Mori T, etal |title=Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions. |journal=Am. J. Pathol. |volume=141 |issue= 3 |pages= 591–9 |year= 1992 |pmid= 1519666 |doi=  | pmc=1886699  }}
*{{cite journal  |vauthors=Matsumoto A, Naito M, Itakura H, etal |title=Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9133–7 |year= 1991 |pmid= 2251254 |doi=10.1073/pnas.87.23.9133  | pmc=55118  }}
*{{cite journal  |vauthors=Matsumoto A, Naito M, Itakura H, etal |title=Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 23 |pages= 9133–7 |year= 1991 |pmid= 2251254 |doi=10.1073/pnas.87.23.9133  | pmc=55118  |bibcode=1990PNAS...87.9133M }}
*{{cite journal  |vauthors=Emi M, Asaoka H, Matsumoto A, etal |title=Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 2120–5 |year= 1993 |pmid= 8093617 |doi=  }}
*{{cite journal  |vauthors=Emi M, Asaoka H, Matsumoto A, etal |title=Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 3 |pages= 2120–5 |year= 1993 |pmid= 8093617 |doi=  }}
*{{cite journal  |vauthors=Ashkenas J, Penman M, Vasile E, etal |title=Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. |journal=J. Lipid Res. |volume=34 |issue= 6 |pages= 983–1000 |year= 1993 |pmid= 8394868 |doi=  }}
*{{cite journal  |vauthors=Ashkenas J, Penman M, Vasile E, etal |title=Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. |journal=J. Lipid Res. |volume=34 |issue= 6 |pages= 983–1000 |year= 1993 |pmid= 8394868 |doi=  }}
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*{{cite journal  |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 321–5 |year= 2002 |pmid= 12244320 |doi= 10.1038/ng994 }}
*{{cite journal  |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 321–5 |year= 2002 |pmid= 12244320 |doi= 10.1038/ng994 }}
*{{cite journal  |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 208–12 |year= 2003 |pmid= 12471593 |doi=10.1086/345802  | pmc=378627  }}
*{{cite journal  |vauthors=Xu J, Zheng SL, Komiya A, etal |title=Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 208–12 |year= 2003 |pmid= 12471593 |doi=10.1086/345802  | pmc=378627  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Kosswig N, Rice S, Daugherty A, Post SR |title=Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34219–25 |year= 2003 |pmid= 12819208 |doi= 10.1074/jbc.M303465200 }}
*{{cite journal  |vauthors=Kosswig N, Rice S, Daugherty A, Post SR |title=Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34219–25 |year= 2003 |pmid= 12819208 |doi= 10.1074/jbc.M303465200 }}
*{{cite journal  |vauthors=Miller DC, Zheng SL, Dunn RL, etal |title=Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3486–9 |year= 2003 |pmid= 12839931 |doi=  }}
*{{cite journal  |vauthors=Miller DC, Zheng SL, Dunn RL, etal |title=Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3486–9 |year= 2003 |pmid= 12839931 |doi=  }}

Latest revision as of 08:41, 10 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
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RefSeq (mRNA)

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RefSeq (protein)

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Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.[1][2]

MSR1 has also recently been designated CD204 (cluster of differentiation 204).

Function

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. They were thought to be expressed macrophage-specific, but recently shown to be present on different dendritic cells classes, too.[3]

The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.[1]

Biotechnology application

Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic.[4]

Interactions

MSR1 has been shown to interact with HSPA1A.[5]

References

  1. 1.0 1.1 "Entrez Gene: MSR1 macrophage scavenger receptor 1".
  2. Matsumoto A, Naito M, Itakura H, Ikemoto S, Asaoka H, Hayakawa I, Kanamori H, Aburatani H, Takaku F, Suzuki H (December 1990). "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9133–7. Bibcode:1990PNAS...87.9133M. doi:10.1073/pnas.87.23.9133. PMC 55118. PMID 2251254.
  3. Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI (August 2010). "Lipid accumulation and dendritic cell dysfunction in cancer". Nat. Med. 16 (8): 880–6. doi:10.1038/nm.2172. PMC 2917488. PMID 20622859.
  4. Robbins AK, Horlick RA (August 1998). "Macrophage scavenger receptor confers an adherent phenotype to cells in culture". BioTechniques. 25 (2): 240–4. PMID 9714883.
  5. Nakamura, Toshinobu; Hinagata Jun-ichi; Tanaka Toshiki; Imanishi Takeshi; Wada Youichiro; Kodama Tatsuhiko; Doi Takefumi (Jan 2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors". Biochem. Biophys. Res. Commun. United States. 290 (2): 858–64. doi:10.1006/bbrc.2001.6271. ISSN 0006-291X. PMID 11785981.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.