Brodmann area 46
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Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is sandwiched between BA10 and BA45.
This area is known as middle frontal area 46. In the human it occupies approximately the middle third of the middle frontal gyrus and the most rostral portion of the inferior frontal gyrus. Brodmann area 46 roughly corresponds with the dorsolateral prefrontal cortex (DLPFC), though the borders of area 46 are based on cytoarchitecture rather than function. The DLPFC also encompasses part of granular frontal area 9, directly adjacent on the dorsal surface of the cortex.
Cytoarchitecturally, area 46 it is bounded dorsally by the granular frontal area 9, rostroventrally by the frontopolar area 10 and caudally by the triangular area 45 (Brodmann-1909). There is some discrepancy between the exetent of Brodman's area 8 (1905) and the same area as described by Walker (1940)[1]
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Function
The DLPFC plays a role in sustaining attention and working memory. Lesions to the DLPFC impair short-term memory and cause difficulty inhibiting responses. Lesions may also eliminate much of the ability to make judgements about what's relevant and what's not.
References
- ↑ Petrides, M., Pandya, D.M., (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience, Vol. 11, pp. 1011–1036
- Petrides, M., Pandya, D.M., (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience, Vol. 11, pp. 1011–1036
External links
- For Neuroanatomy of the area visit BrainInfo
See also
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
