CD29

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Identifiers
Symbol(s)	ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLAB
External IDs	OMIM: 135630 MGI: 96610 Homologene: 22999
Gene ontology Molecular Function: • receptor activity • protein binding • identical protein binding • protein heterodimerization activity Cellular Component: • ruffle • endoplasmic reticulum • integrin complex • membrane • integral to membrane Biological Process: • cellular defense response • cell adhesion • homophilic cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development • cell migration
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3688	16412
Ensembl	ENSG00000150093	ENSMUSG00000025809
Uniprot	P05556	Q3TIW5
Refseq	NM_002211 (mRNA) NP_002202 (protein)	NM_010578 (mRNA) NP_034708 (protein)
Location	Chr 10: 33.23 - 33.29 Mb	Chr 8: 131.59 - 131.62 Mb
Pubmed search	[1]	[2]

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors.

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

Further reading

• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". Bioessays 23 (7): 628-39. doi:10.1002/bies.1088. PMID 11462216.
• Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions.". Front. Biosci. 7: d219-27. PMID 11779688.
• Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more.". Cancer Metastasis Rev. 24 (3): 403-11. doi:10.1007/s10555-005-5132-5. PMID 16258728.

External links

• MeSH CD29+Antigen