SLC5A6: Difference between revisions

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Latest revision as of 15:28, 11 November 2017

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.^[1]^[2]^[3]

It is a putative transporter for uptake of biotin and pantothenic acid at the blood-brain barrier.^[4]

References

↑ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
↑ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
↑ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
↑ Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

Prasad PD, Wang H, Huang W, et al. (1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Arch. Biochem. Biophys. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
Zempleni J, Steven Stanley J, Mock DM (2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
Dey S, Subramanian VS, Chatterjee NS, et al. (2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochim. Biophys. Acta. 1574 (2): 187–92. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Balamurugan K, Ortiz A, Said HM (2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (1): G73–7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Balamurugan K, Vaziri ND, Said HM (2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". Am. J. Physiol. Renal Physiol. 288 (4): F823–31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Luo S, Kansara VS, Zhu X, et al. (2006). "Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery". Mol. Pharm. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865.
Reidling JC, Nabokina SM, Said HM (2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G275–81. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
Reidling JC, Said HM (2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". Am. J. Physiol., Cell Physiol. 292 (4): C1305–12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid9516450-1] Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.

[pmid10329687-2] Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.

[entrez-3] "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".

[Uchida_2015-4] Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Sodium-dependent multivitamin transporter''' is a [[protein]] that in humans is encoded by the ''SLC5A6'' [[gene]].<ref name="pmid9516450">{{cite journal | vauthors = Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V | title = Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate | journal = J Biol Chem | volume = 273 | issue = 13 | pages = 7501–6 |date=Apr 1998 | pmid = 9516450 | pmc =  | doi =10.1074/jbc.273.13.7501  }}</ref><ref name="pmid10329687">{{cite journal | vauthors = Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD | title = Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization | journal = J Biol Chem | volume = 274 | issue = 21 | pages = 14875–83 |date=Jul 1999 | pmid = 10329687 | pmc =  | doi =10.1074/jbc.274.21.14875  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8884| accessdate = }}</ref>
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+It is a putative transporter for uptake of [[biotin]] and [[pantothenic acid]] at the [[blood-brain barrier]].<ref name="Uchida_2015">{{cite journal | vauthors = Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T | title = Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells | journal = Journal of Neurochemistry | volume = 134 | issue = 1 | pages = 97–112 | year = 2015 | pmid = 25809983 | doi = 10.1111/jnc.13092 }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 5 (sodium-dependent vitamin transporter), member 6
- | HGNCid = 11041
- | Symbol = SLC5A6
- | AltSymbols =; SMVT
- | OMIM = 604024
- | ECnumber =
- | Homologene = 23277
- | MGIid = 2660847
- | GeneAtlas_image1 = PBB_GE_SLC5A6_204087_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0008523 |text = sodium-dependent multivitamin transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8884
-    | Hs_Ensembl = ENSG00000138074
-    | Hs_RefseqProtein = NP_066918
-    | Hs_RefseqmRNA = NM_021095
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 27275959
-    | Hs_GenLoc_end = 27288658
-    | Hs_Uniprot = Q9Y289
-    | Mm_EntrezGene = 330064
-    | Mm_Ensembl = ENSMUSG00000006641
-    | Mm_RefseqmRNA = NM_177870
-    | Mm_RefseqProtein = NP_808538
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 31312617
-    | Mm_GenLoc_end = 31325505
-    | Mm_Uniprot = Q3TY45
-  }}
-}}
-'''Solute carrier family 5 (sodium-dependent vitamin transporter), member 6''', also known as '''SLC5A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8884| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+==References==
-{{PBB_Summary
+{{reflist}}
-| section_title =
-| summary_text =
-}}
-==References==
-{{reflist|2}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Prasad PD, Wang H, Huang W, etal |title=Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. |journal=Arch. Biochem. Biophys. |volume=366 |issue= 1 |pages= 95–106 |year= 1999 |pmid= 10334869 |doi= 10.1006/abbi.1999.1213 }}
-| citations =
+*{{cite journal  | vauthors=Zempleni J, Steven Stanley J, Mock DM |title=Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star |journal= The Journal of Nutritional Biochemistry|volume=12 |issue= 8 |pages= 465–473 |year=  2001|pmid= 11834205 |doi=10.1016/S0955-2863(01)00162-0  }}
-*{{cite journal  | author=Prasad PD, Wang H, Kekuda R, ''et al.'' |title=Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7501-6 |year= 1998 |pmid= 9516450 |doi=  }}
+*{{cite journal   |vauthors=Dey S, Subramanian VS, Chatterjee NS, etal |title=Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 2 |pages= 187–92 |year= 2002 |pmid= 11955628 |doi=  10.1016/s0167-4781(02)00226-9}}
-*{{cite journal  | author=Wang H, Huang W, Fei YJ, ''et al.'' |title=Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14875-83 |year= 1999 |pmid= 10329687 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Prasad PD, Wang H, Huang W, ''et al.'' |title=Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter. |journal=Arch. Biochem. Biophys. |volume=366 |issue= 1 |pages= 95-106 |year= 1999 |pmid= 10334869 |doi= 10.1006/abbi.1999.1213 }}
+*{{cite journal  | vauthors=Balamurugan K, Ortiz A, Said HM |title=Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=285 |issue= 1 |pages= G73–7 |year= 2003 |pmid= 12646417 |doi= 10.1152/ajpgi.00059.2003 }}
-*{{cite journal  | author=Zempleni J, Steven Stanley J, Mock DM |title=Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star |journal= |volume=12 |issue= 8 |pages= 465-473 |year=  |pmid= 11834205 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Dey S, Subramanian VS, Chatterjee NS, ''et al.'' |title=Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 2 |pages= 187-92 |year= 2002 |pmid= 11955628 |doi=  }}
+*{{cite journal  | vauthors=Balamurugan K, Vaziri ND, Said HM |title=Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects |journal=Am. J. Physiol. Renal Physiol. |volume=288 |issue= 4 |pages= F823–31 |year= 2005 |pmid= 15561972 |doi= 10.1152/ajprenal.00375.2004 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-*{{cite journal  | author=Balamurugan K, Ortiz A, Said HM |title=Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=285 |issue= 1 |pages= G73-7 |year= 2003 |pmid= 12646417 |doi= 10.1152/ajpgi.00059.2003 }}
+*{{cite journal   |vauthors=Luo S, Kansara VS, Zhu X, etal |title=Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery |journal=Mol. Pharm. |volume=3 |issue= 3 |pages= 329–39 |year= 2006 |pmid= 16749865 |doi= 10.1021/mp0500768  | pmc=2553563 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Reidling JC, Nabokina SM, Said HM |title=Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=292 |issue= 1 |pages= G275–81 |year= 2007 |pmid= 16959947 |doi= 10.1152/ajpgi.00327.2006 }}
-*{{cite journal  | author=Balamurugan K, Vaziri ND, Said HM |title=Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects. |journal=Am. J. Physiol. Renal Physiol. |volume=288 |issue= 4 |pages= F823-31 |year= 2005 |pmid= 15561972 |doi= 10.1152/ajprenal.00375.2004 }}
+*{{cite journal  | vauthors=Reidling JC, Said HM |title=Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 4 |pages= C1305–12 |year= 2007 |pmid= 17135299 |doi= 10.1152/ajpcell.00360.2006 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-*{{cite journal  | author=Luo S, Kansara VS, Zhu X, ''et al.'' |title=Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. |journal=Mol. Pharm. |volume=3 |issue= 3 |pages= 329-39 |year= 2006 |pmid= 16749865 |doi= 10.1021/mp0500768 }}
-*{{cite journal  | author=Reidling JC, Nabokina SM, Said HM |title=Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=292 |issue= 1 |pages= G275-81 |year= 2007 |pmid= 16959947 |doi= 10.1152/ajpgi.00327.2006 }}
-*{{cite journal  | author=Reidling JC, Said HM |title=Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. |journal=Am. J. Physiol., Cell Physiol. |volume=292 |issue= 4 |pages= C1305-12 |year= 2007 |pmid= 17135299 |doi= 10.1152/ajpcell.00360.2006 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{Solute carrier family|bg|bg0}}
-{{WikiDoc Sources}}
+{{gene-2-stub}}

SLC5A6: Difference between revisions

Latest revision as of 15:28, 11 November 2017

References

Further reading

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