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'''Corticotropin-like intermediate [lobe] peptide''' ('''CLIP'''), also known as '''adrenocorticotropic hormone fragment 18-39''' ('''ACTH'''('''18-39''')), is a [[natural product|naturally occurring]], [[endogenous]] [[neuropeptide]] with a [[docosapeptide]] [[chemical structure|structure]] and the [[amino acid sequence]] Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a [[proteolyic]] [[bond cleavage|cleavage product]] of [[adrenocorticotropic hormone]] (ACTH),<ref name="pmid227883">{{cite journal |vauthors=Gianoulakis C, Seidah NG, Routhier R, Chrétien M | title = Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia | journal = The Journal of Biological Chemistry | volume = 254 | issue = 23 | pages = 11903–6 |date=December 1979 | pmid = 227883 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=227883}}</ref><ref name="Fricker1991">{{cite book | author = Lloyd D. Fricker | title = Peptide biosynthesis and processing | url = https://books.google.com/books?id=cvvW1e3T__sC&pg=PA78 | accessdate = 25 November 2011 | date = 24 July 1991 | publisher = CRC Press | isbn = 978-0-8493-8852-1 | pages = 78}}</ref> which in turn is a cleavage product of [[proopiomelanocortin]] (POMC).<ref name="NormanLitwack1997">{{cite book | author1 = Anthony W. Norman | author2 = Gerald Litwack | title = Hormones | url = https://books.google.com/books?id=OWxLaKew8sQC&pg=PA12 | accessdate = 25 November 2011 | date = 26 September 1997 | publisher = Academic Press | isbn = 978-0-12-521441-4 | pages = 12}}</ref> Its physiological role has been investigated in various tissues,<ref name="pmid6209301">{{cite journal |vauthors=Marshall JB, Kapcala LP, Manning LD, McCullough AJ | title = Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules | journal = The Journal of Clinical Investigation | volume = 74 | issue = 5 | pages = 1886–9 |date=November 1984 | pmid = 6209301 | pmc = 425369 | doi = 10.1172/JCI111608 }}</ref><ref name="pmid1849784">{{cite journal |vauthors=Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C | title = Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain | journal = Brain Research Bulletin | volume = 26 | issue = 1 | pages = 99–111 |date=January 1991 | pmid = 1849784 | doi = 10.1016/0361-9230(91)90194-O| url = http://linkinghub.elsevier.com/retrieve/pii/0361-9230(91)90194-O}}</ref> specifically in the [[central nervous system]].<ref name="InouéInoué1989">{{cite book | author1 = Shojiro Inoué | author2 = Shojiro Inoué | title = Biology of sleep substances | url = https://books.google.com/books?id=rT7clpjUwaEC&pg=PA136 | accessdate = 25 November 2011 | year = 1989 | publisher = CRC Press | isbn = 978-0-8493-4822-8 | pages = 136}}</ref><ref name="pmid1981927">{{cite journal |vauthors=Chastrette N, Cespuglio R, Jouvet M | title = Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives | journal = Neuropeptides | volume = 15 | issue = 2 | pages = 61–74 |date=February 1990 | pmid = 1981927 | doi = 10.1016/0143-4179(90)90042-w| url = }}</ref><ref name="pmid1964203">{{cite journal |vauthors=Chastrette N, Cespuglio R, Lin YL, Jouvet M | title = Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes | journal = Neuropeptides | volume = 15 | issue = 2 | pages = 75–88 |date=February 1990 | pmid = 1964203 | doi = 10.1016/0143-4179(90)90043-x| url = }}</ref><ref name="pmid19529852">{{cite journal |vauthors=Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP | title = Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain | journal = Bulletin of Experimental Biology and Medicine | volume = 147 | issue = 3 | pages = 319–22 |date=March 2009 | pmid = 19529852 | doi = 10.1007/s10517-009-0499-x| url = }}</ref><ref name="pmid8134304">{{cite journal |vauthors=Seidenbecher T, Balschun D, Vogel D, Reymann KG | title = Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)] | journal = Peptides | volume = 14 | issue = 6 | pages = 1221–4 | year = 1993 | pmid = 8134304 | doi = 10.1016/0196-9781(93)90179-K| url = http://linkinghub.elsevier.com/retrieve/pii/0196-9781(93)90179-K}}</ref>
'''Corticotropin-like intermediate [lobe] peptide''' ('''CLIP'''), also known as '''adrenocorticotropic hormone fragment 18-39''' ('''ACTH'''('''18-39''')), is a [[natural product|naturally occurring]], [[endogenous]] [[neuropeptide]] with a [[docosapeptide]] [[chemical structure|structure]] and the [[amino acid sequence]] Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a [[proteolyic]] [[bond cleavage|cleavage product]] of [[adrenocorticotropic hormone]] (ACTH),<ref name="pmid227883">{{cite journal |vauthors=Gianoulakis C, Seidah NG, Routhier R, Chrétien M | title = Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia | journal = The Journal of Biological Chemistry | volume = 254 | issue = 23 | pages = 11903–6 |date=December 1979 | pmid = 227883 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=227883}}</ref><ref name="Fricker1991">{{cite book | author = Lloyd D. Fricker | title = Peptide biosynthesis and processing | url = https://books.google.com/books?id=cvvW1e3T__sC&pg=PA78 | accessdate = 25 November 2011 | date = 24 July 1991 | publisher = CRC Press | isbn = 978-0-8493-8852-1 | pages = 78}}</ref> which in turn is a cleavage product of [[proopiomelanocortin]] (POMC).<ref name="NormanLitwack1997">{{cite book | author1 = Anthony W. Norman | author2 = Gerald Litwack | title = Hormones | url = https://books.google.com/books?id=OWxLaKew8sQC&pg=PA12 | accessdate = 25 November 2011 | date = 26 September 1997 | publisher = Academic Press | isbn = 978-0-12-521441-4 | pages = 12}}</ref> Although it does not appear to play any particularly important roles in the body,<ref name="Engelking2002">{{cite book | author = Larry Rex Engelking | title = Review of veterinary physiology | url = https://books.google.com/books?id=CV277NJHlwwC&pg=PA411 | accessdate = 25 November 2011 | date = 1 June 2002 | publisher = Teton NewMedia | isbn = 978-1-893441-69-9 | pages = 411}}</ref> it does have some biological activity,<ref name="pmid6209301">{{cite journal |vauthors=Marshall JB, Kapcala LP, Manning LD, McCullough AJ | title = Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules | journal = The Journal of Clinical Investigation | volume = 74 | issue = 5 | pages = 1886–9 |date=November 1984 | pmid = 6209301 | pmc = 425369 | doi = 10.1172/JCI111608 | url = https://dx.doi.org/10.1172/JCI111608}}</ref><ref name="pmid1849784">{{cite journal |vauthors=Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C | title = Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain | journal = Brain Research Bulletin | volume = 26 | issue = 1 | pages = 99–111 |date=January 1991 | pmid = 1849784 | doi = 10.1016/0361-9230(91)90194-O| url = http://linkinghub.elsevier.com/retrieve/pii/0361-9230(91)90194-O}}</ref> particularly neurological.<ref name="InouéInoué1989">{{cite book | author1 = Shojiro Inoué | author2 = Shojiro Inoué | title = Biology of sleep substances | url = https://books.google.com/books?id=rT7clpjUwaEC&pg=PA136 | accessdate = 25 November 2011 | year = 1989 | publisher = CRC Press | isbn = 978-0-8493-4822-8 | pages = 136}}</ref><ref name="pmid1981927">{{cite journal |vauthors=Chastrette N, Cespuglio R, Jouvet M | title = Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives | journal = Neuropeptides | volume = 15 | issue = 2 | pages = 61–74 |date=February 1990 | pmid = 1981927 | doi = 10.1016/0143-4179(90)90042-w| url = }}</ref><ref name="pmid1964203">{{cite journal |vauthors=Chastrette N, Cespuglio R, Lin YL, Jouvet M | title = Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes | journal = Neuropeptides | volume = 15 | issue = 2 | pages = 75–88 |date=February 1990 | pmid = 1964203 | doi = 10.1016/0143-4179(90)90043-x| url = }}</ref><ref name="pmid19529852">{{cite journal |vauthors=Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP | title = Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain | journal = Bulletin of Experimental Biology and Medicine | volume = 147 | issue = 3 | pages = 319–22 |date=March 2009 | pmid = 19529852 | doi = 10.1007/s10517-009-0499-x| url = }}</ref><ref name="pmid8134304">{{cite journal |vauthors=Seidenbecher T, Balschun D, Vogel D, Reymann KG | title = Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)] | journal = Peptides | volume = 14 | issue = 6 | pages = 1221–4 | year = 1993 | pmid = 8134304 | doi = 10.1016/0196-9781(93)90179-K| url = http://linkinghub.elsevier.com/retrieve/pii/0196-9781(93)90179-K}}</ref>


== References ==
== References ==

Latest revision as of 16:46, 7 November 2018

pro-opiomelanocortin
Identifiers
SymbolPOMC
Entrez5443
HUGO9201
OMIM176830
RefSeqNM_000939
UniProtP01189
Other data
LocusChr. 2 p23
Template:Chembox E number
Corticotropin-like intermediate peptide
Names
IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
Identifiers
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
Properties
C112H165N27O36
Molar mass 2465.668 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Its physiological role has been investigated in various tissues,[4][5] specifically in the central nervous system.[6][7][8][9][10]

References

  1. ↑ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883.
  2. ↑ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78. ISBN 978-0-8493-8852-1. Retrieved 25 November 2011.
  3. ↑ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. p. 12. ISBN 978-0-12-521441-4. Retrieved 25 November 2011.
  4. ↑ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
  5. ↑ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.
  6. ↑ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136. ISBN 978-0-8493-4822-8. Retrieved 25 November 2011.
  7. ↑ Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.
  8. ↑ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.
  9. ↑ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.
  10. ↑ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.

External links


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