SLCO1B3: Difference between revisions

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== Clinical significance ==
== Clinical significance ==
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.<ref name="pmid18519758">{{cite journal | vauthors = Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer | journal = Clin. Cancer Res. | volume = 14 | issue = 11 | pages = 3312–8 |date=June 2008 | pmid = 18519758 | pmc = 2701141 | doi = 10.1158/1078-0432.CCR-07-4118 | url = | issn = }}</ref> Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.<ref name="pmid21625523">{{cite journal | author = Heather Pressler | author2 = Tristan M. Sissung | author3 = David Venzon| author4 = Douglas K. Price | author5 = William D. Figg | title = Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression | journal = Clin. Cancer Res. | volume = 6 | issue = 5 | pages = e20372 |date=May 2011 | pmid = 21625523 | pmc = 3098289 | doi = 10.1371/journal.pone.0020372| url =http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020372 | issn = }}</ref>
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.<ref name="pmid18519758">{{cite journal | vauthors = Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer | journal = Clin. Cancer Res. | volume = 14 | issue = 11 | pages = 3312–8 |date=June 2008 | pmid = 18519758 | pmc = 2701141 | doi = 10.1158/1078-0432.CCR-07-4118 | url = | issn = }}</ref> Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.<ref name="pmid21625523">{{cite journal | author = Heather Pressler | author2 = Tristan M. Sissung | author3 = David Venzon| author4 = Douglas K. Price | author5 = William D. Figg | title = Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression | journal = Clin. Cancer Res. | volume = 6 | issue = 5 | pages = e20372 |date=May 2011 | pmid = 21625523 | pmc = 3098289 | doi = 10.1371/journal.pone.0020372| issn = | bibcode = 2011PLoSO...620372P }}</ref>


In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.<ref name="pmid21625523" />
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.<ref name="pmid21625523" />
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*{{cite journal  | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 }}
*{{cite journal  | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 }}
*{{cite journal  |vauthors=Abe T, Unno M, Onogawa T, etal |title=LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1689–99 |year= 2001 |pmid= 11375950 |doi=10.1053/gast.2001.24804  }}
*{{cite journal  |vauthors=Abe T, Unno M, Onogawa T, etal |title=LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1689–99 |year= 2001 |pmid= 11375950 |doi=10.1053/gast.2001.24804  }}
*{{cite journal  |vauthors=Ismair MG, Stieger B, Cattori V, etal |title=Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver |journal=Gastroenterology |volume=121 |issue= 5 |pages= 1185–90 |year= 2001 |pmid= 11677211 |doi=10.1053/gast.2001.28704  }}
*{{cite journal  |vauthors=Ismair MG, Stieger B, Cattori V, etal |title=Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver |journal=Gastroenterology |volume=121 |issue= 5 |pages= 1185–90 |year= 2001 |pmid= 11677211 |doi=10.1053/gast.2001.28704  |url=http://www.zora.uzh.ch/id/eprint/3000/4/ZORA_3000.pdf }}
*{{cite journal  |vauthors=Jung D, Podvinec M, Meyer UA, etal |title=Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor |journal=Gastroenterology |volume=122 |issue= 7 |pages= 1954–66 |year= 2002 |pmid= 12055601 |doi=10.1053/gast.2002.33583  }}
*{{cite journal  |vauthors=Jung D, Podvinec M, Meyer UA, etal |title=Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor |journal=Gastroenterology |volume=122 |issue= 7 |pages= 1954–66 |year= 2002 |pmid= 12055601 |doi=10.1053/gast.2002.33583  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Cui Y, König J, Nies AT, etal |title=Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma |journal=Lab. Invest. |volume=83 |issue= 4 |pages= 527–38 |year= 2003 |pmid= 12695556 |doi=  10.1097/01.lab.0000065015.02412.48}}
*{{cite journal  |vauthors=Cui Y, König J, Nies AT, etal |title=Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma |journal=Lab. Invest. |volume=83 |issue= 4 |pages= 527–38 |year= 2003 |pmid= 12695556 |doi=  10.1097/01.lab.0000065015.02412.48}}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}

Latest revision as of 10:38, 30 December 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[1]

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[2] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[3]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[3]

Substrates

Small molecules that are transported by SLCO1B3 include:[4]

See also

References

  1. ↑ "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  2. ↑ Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  3. ↑ 3.0 3.1 Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". Clin. Cancer Res. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  4. ↑ Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430.

Further reading


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