Sodium-hydrogen antiporter 3

Solute carrier family 9 (sodium/hydrogen exchanger), member 3
Identifiers
Symbol(s)	SLC9A3; MGC126718; MGC126720; NHE3
External IDs	OMIM: 182307 MGI: 105064 Homologene: 55804
Gene ontology Molecular Function: • antiporter activity • solute:hydrogen antiporter activity • sodium:hydrogen antiporter activity • sodium ion binding Cellular Component: • membrane • integral to membrane • apical plasma membrane Biological Process: • ion transport • sodium ion transport • regulation of pH
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6550	105243
Ensembl	ENSG00000066230	ENSMUSG00000036123
Uniprot	P48764	na
Refseq	NM_004174 (mRNA) NP_004165 (protein)	XM_127434 (mRNA) XP_127434 (protein)
Location	Chr 5: 0.53 - 0.58 Mb	Chr 13: 74.59 - 74.63 Mb
Pubmed search	[1]	[2]

Sodium-hydrogen antiporter 3 or Sodium-hydrogen exchanger 3 (NHE3) is an isoform of sodium-hydrogen antiporters. It is found in the nephron of the kidney and is primarily responsible for maintaining the balance of sodium.

Regulation

Protein kinase C stimulates NHE3, while protein kinase A inhibits it.

There is a specific protein functioning as an NHE3 regulator, sodium-hydrogen antiporter 3 regulator 1.

Classification

It is a solute carrier family 9 (sodium/hydrogen exchanger), member 3

Gene

It is encoded by the gene SLC9A3.

Further reading

• McDonough AA, Leong PK, Yang LE (2003). "Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport.". Ann. N. Y. Acad. Sci. 986: 669-77. PMID 12763917.
• Orlowski J, Kandasamy RA, Shull GE (1992). "Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.". J. Biol. Chem. 267 (13): 9331-9. PMID 1577762.
• Brant SR, Yun CH, Donowitz M, Tse CM (1995). "Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.". Am. J. Physiol. 269 (1 Pt 1): C198-206. PMID 7631746.
• Brant SR, Bernstein M, Wasmuth JJ, et al. (1993). "Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3.". Genomics 15 (3): 668-72. PMID 8096830.
• Colombani V, Silviani V, Marteau C, et al. (1996). "Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder.". Clin. Sci. 91 (2): 209-12. PMID 8795445.
• Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.". Am. J. Physiol. 271 (3 Pt 1): G483-93. PMID 8843774.
• Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631-6. PMID 8901634.
• Yun CH, Lamprecht G, Forster DV, Sidor A (1998). "NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin.". J. Biol. Chem. 273 (40): 25856-63. PMID 9748260.
• Biemesderfer D, Nagy T, DeGray B, Aronson PS (1999). "Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule.". J. Biol. Chem. 274 (25): 17518-24. PMID 10364184.
• Mobasheri A, Golding S, Pagakis SN, et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts.". Cell Biol. Int. 22 (7-8): 551-62. doi:10.1006/cbir.1998.0299. PMID 10452823.
• Trujillo E, Alvarez de la Rosa D, Mobasheri A, et al. (1999). "Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes.". Histol. Histopathol. 14 (4): 1023-31. PMID 10506918.
• Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159-63. PMID 11408268.
• Malakooti J, Memark VC, Dudeja PK, Ramaswamy K (2002). "Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G491-500. doi:10.1152/ajpgi.00273.2001. PMID 11841999.
• Gekle M, Serrano OK, Drumm K, et al. (2002). "NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis.". Am. J. Physiol. Renal Physiol. 283 (3): F549-58. doi:10.1152/ajprenal.00206.2001. PMID 12167607.
• Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT (2003). "Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity.". Pflugers Arch. 445 (1): 139-46. doi:10.1007/s00424-002-0910-1. PMID 12397398.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Lee SH, Seok YS, Jung HH, et al. (2003). "Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa.". Acta Otolaryngol. 122 (8): 866-71. PMID 12542207.
• Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.". Biol. Pharm. Bull. 26 (2): 148-55. PMID 12576672.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.

External links

• MeSH Sodium-Hydrogen+Exchanger