ACVR1C
| Activin receptor type 1C | |
|---|---|
| Other names: | ACTR-IC, Activin receptor-like kinase 7, ALK-7 |
| Genetic data | |
| Gene code: | HUGO code:ACVR1C |
| Protein Structure/Function | |
| Protein type: | Serine/Threonine receptor kinase |
| Domains: | GS domain, TS domain, S/T domain |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | ubiquitous |
| Subcellular localization: | Plasma membrane |
| Enzymatic Data | |
| Catalytic activity: | ATP + (receptor-protein) = ADP + (receptor-protein) phosphate |
| Cofactor(s): | Magnesium or manganese |
ACVR1C or ALK-7 transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1]
| '
| |
| Identifiers | |
| Symbol | ACVR1C |
| Entrez | 130399 |
| HUGO | 18123 |
| OMIM | 608981 |
| RefSeq | NM_145259 |
| UniProt | Q8NER5 |
| Other data | |
| Locus | Chr. 2 q24.2 |
References
- ↑ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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