Bone morphogenetic protein 15

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Bone Morphogentic Protein 15
Other names:	Growth differentiation factor 9B (GDF9b)
Genetic data
Locus:	Chr. X p11.2
Gene code:	HUGO code: BMP15
Protein Structure/Function
Functions:	cell signaling
Domains:	TGFβ
Other
Taxa expressing:	many metazoan phyla
Cell types:	mesenchymal
Medical/Biotechnological data
Diseases:	ovarian disgenesis 2
Database Links
Entrez:	9210
OMIM:	300247
RefSeq:	NM_005448
UniProt:	O95972

Bone morphogenetic protein 15 is a member of the TGF-β superfamily of proteins. It is a paracrine signaling molecule involved in oocyte and follicular development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It can be a homodimer or heterodimer.

v • d • e Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal)
TGF beta receptors	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan
Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors	Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
Coreceptors	BAMBI - Cripto
Other	SARA