Ataxia telangiectasia mutated

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Ataxia telangiectasia mutated
Identifiers
Symbol	ATM
Alt. Symbols	ATA; ATDC; TEL1
Entrez	472
HUGO	795
OMIM	607585
RefSeq	NM_138293
UniProt	Q13315
Other data
EC number	2.7.1.37
Locus	Chr. 11 q22-23

Ataxia telangiectasia mutated (ATM) is a serine/threonine-specific protein kinase (EC 2.7.11.1) that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, and H2AX are tumor suppressors.

The protein is named for the disorder Ataxia telangiectasia caused by mutations of ATM.

External links

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v • d • e Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)
2.7.11	Pyruvate dehydrogenase kinase - Protein kinase A - Protein kinase G - Protein kinase C (Protein kinase Mζ) - Rhodopsin - Beta adrenergic receptor - G-protein coupled receptor kinases - Ca2+/calmodulin-dependent - Myosin light-chain) - Phosphorylase - Cyclin-dependent - Mitogen-activated (Extracellular signal-regulated, C-Jun N-terminal (MAPK8, MAPK9), P38 mitogen-activated protein) - MAP3K - GSK-3 - AMP-activated
2.7.12	MAP2K (1, 2, 3, 4, 5, 6, 7)
2.7.1.37, or unknown	Anti-Mullerian hormone receptor - Ataxia telangiectasia mutated - Aurora (A, B) - Mammalian target of rapamycin - Bone morphogenetic protein receptors (1, 2) - CDKL5 - c-Raf - EIF-2 - Ribosomal s6 - Protein kinase B - PDK1