GDF3
| growth differentiation factor 3
| |
| Identifiers | |
| Symbol | GDF3 |
| Entrez | 9573 |
| HUGO | 4218 |
| OMIM | 606522 |
| RefSeq | NM_020634 |
| UniProt | Q9NR23 |
| Other data | |
| Locus | Chr. 12 p13.1 |
Growth differentiation factor-3 (GDF3) is also known as Vg-related gene 2 (Vgr-2) is protein belonging to the transforming growth factor beta (TGF-β) superfamily.
It has high similarity to other TGF-β superfamily members called Vg1 (found in frogs), BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.[1] Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.[2][3]
GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.[4] It has been shown to negatively and positively control differentiation of embryonic stem cells in mice and humans.[5] This molecule plays a role in mesoderm and definitive endoderm formation during the pre-gastrulation stages of development.[6]
References
- ↑ Caricasole A, van Schaik R, Zeinstra L, Wierikx C, van Gurp R, van den Pol M, Looijenga L, Oosterhuis J, Pera M, Ward A, de Bruijn D, Kramer P, de Jong F, van den Eijnden-van Raaij A (1998). "Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours". Oncogene 16 (1): 95-103. PMID 9467948.
- ↑ Chen C, Ware S, Sato A, Houston-Hawkins D, Habas R, Matzuk M, Shen M, Brown C (2006). "The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo". Development 133 (2): 319-29. PMID 16368929.
- ↑ Hexige S, Guo J, Ma L, Sun Y, Liu X, Ma L, Yan X, Li Z, Yu L (2005). "Expression pattern of growth/differentiation factor 3 in human and murine cerebral cortex, hippocampus as well as cerebellum". Neurosci Lett 389 (2): 83-7. PMID 16126341.
- ↑ Levine A, Brivanlou A (2006). "GDF3 at the crossroads of TGF-beta signaling". Cell Cycle 5 (10): 1069-73. PMID 16721050.
- ↑ Levine A, Brivanlou A (2006). "GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos". Development 133 (2): 209-16. PMID 16339188.
- ↑ Chen C, Ware S, Sato A, Houston-Hawkins D, Habas R, Matzuk M, Shen M, Brown C (2006). "The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo". Development 133 (2): 319-29. PMID 16368929.
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Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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