ACVRL1
| activin A receptor type II-like 1
| |
| Identifiers | |
| Symbol | ACVRL1 |
| Alt. Symbols | ACVRLK1, ORW2 |
| Entrez | 94 |
| HUGO | 175 |
| OMIM | 601284 |
| RefSeq | NM_000020 |
| UniProt | P37023 |
| Other data | |
| Locus | Chr. 12 q11-q14 |
Overview
ACVRL1 is a receptor in the TGF beta signaling pathway.
It is also known as "activin receptor-like kinase 1", or "ALK1".
Pathology
It is associated with hereditary hemorrhagic telangiectasia.
Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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