Cyclin-dependent kinase 2

Cyclin-dependent kinase 2
PDB rendering based on 1aq1.
Available structures: 1aq1, 1b38, 1b39, 1buh, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1f5q, 1fin, 1fq1, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gy3, 1gz8, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1h1p, 1h1q, 1h1r, 1h1s, 1h24, 1h25, 1h26, 1h27, 1h28, 1hck, 1hcl, 1jst, 1jsu, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1ogu, 1oi9, 1oiq, 1oir, 1oit, 1oiu, 1oiy, 1okv, 1okw, 1ol1, 1ol2, 1p2a, 1p5e, 1pf8, 1pkd, 1pw2, 1pxi, 1pxj, 1pxk, 1pxl, 1pxm, 1pxn, 1pxo, 1pxp, 1pye, 1qmz, 1r78, 1urc, 1urw, 1v1k, 1vyw, 1vyz, 1w0x, 1w8c, 1w98, 1wcc, 1y8y, 1y91, 1ykr, 2a0c, 2a4l, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 2bkz, 2bpm, 2btr, 2bts, 2c4g, 2c5n, 2c5o, 2c5p, 2c5v, 2c5x, 2c5y, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2cch, 2cci, 2cjm, 2clx, 2duv, 2exm, 2fvd, 2g9x, 2i40, 2iw6, 2iw8, 2iw9, 2jgz, 2uue
Identifiers
Symbol(s)	CDK2; p33(CDK2)
External IDs	OMIM: 116953 MGI: 104772 Homologene: 74409
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • cyclin-dependent protein kinase activity • protein binding • ATP binding • transferase activity Cellular Component: • cyclin-dependent protein kinase holoenzyme complex • nucleus • transcription factor complex • cytoplasm Biological Process: • G2/M transition of mitotic cell cycle • regulation of DNA replication • protein amino acid phosphorylation • cell cycle • mitosis • traversing start control point of mitotic cell cycle • positive regulation of cell proliferation • positive regulation of transcription • cell division
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1017	12566
Ensembl	ENSG00000123374	ENSMUSG00000025358
Uniprot	P24941	Q3U307
Refseq	NM_001798 (mRNA) NP_001789 (protein)	NM_016756 (mRNA) NP_058036 (protein)
Location	Chr 12: 54.65 - 54.65 Mb	Chr 10: 128.1 - 128.11 Mb
Pubmed search	[1]	[2]

Cyclin-dependent kinase 2 is part of the cyclin-dependent kinase family.

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Known CDK inhibitors are p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition.

Further reading

• Kaldis P, Aleem E (2007). "Cell cycle sibling rivalry: Cdc2 vs. Cdk2.". Cell Cycle 4 (11): 1491-4. PMID 16258277.
• Moore NL, Narayanan R, Weigel NL (2007). "Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity.". Steroids 72 (2): 202-9. doi:10.1016/j.steroids.2006.11.025. PMID 17207508.

External links

• MeSH Cyclin-Dependent+Kinase+2