Cyclin-dependent kinase 5

	Cyclin-dependent kinase 5
	PDB rendering based on 1h41.
	Available structures: 1h4l, 1ung, 1unh, 1unl
	Identifiers
Symbol(s)	CDK5; PSSALRE
External IDs	OMIM: 123831 MGI: 101765 Homologene: 3623
Gene ontology
Molecular Function:	• nucleotide binding; • cyclin-dependent protein kinase activity; • ErbB-2 class receptor binding; • protein binding; • ATP binding; • transferase activity; • acetylcholine receptor activator activity; • ErbB-3 class receptor binding; • tau-protein kinase activity;
Cellular Component:	• nucleus; • cytoplasm; • cytosol; • membrane; • lamellipodium; • filopodium; • axon; • dendrite; • growth cone; • neuromuscular junction; • cell soma;
Biological Process:	• protein amino acid phosphorylation; • cell cycle; • cell-matrix adhesion; • striated muscle development; • cell proliferation; • embryonic development; • neuron differentiation; • regulation of cell migration; • neurite development; • positive regulation of neuron apoptosis; • axon extension; • cell division;
	RNA expression pattern
	More reference expression data
	Orthologs

Cyclin-dependent kinase 5, also known as CDK5, is a human gene.^[1]^[2] The protein encoded by this gene is part of the cyclin-dependent kinase family.

CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1.^[3]^[4] Dysregulation of this enyzme has been implicated in several neurodegenerative diseases^[5] including Alzheimer's.^[6]

Recently Cdk5 has emerged as an eesential kinase in sensory pathways. Recent reports of Pareek et. al. from NIH suggest its neccesity in pain signaling.

References

↑ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. PMID 1639063.
↑ Demetrick DJ, Zhang H, Beach DH (1994). "Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes". Cytogenet. Cell Genet. 66 (1): 72–4. PMID 8275715.
↑ Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH (1999). "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration". Nature 402 (6762): 615–22. doi:10.1038/45159. PMID 10604467.
↑ Paglini G, Cáceres A (2001). "The role of the Cdk5--p35 kinase in neuronal development". Eur. J. Biochem. 268 (6): 1528–33. doi:10.1046/j.1432-1327.2001.02023.x. PMID 11248669.
↑ Dhavan R, Tsai LH (2001). "A decade of CDK5". Nat. Rev. Mol. Cell Biol. 2 (10): 749–59. doi:10.1038/35096019. PMID 11584302.
↑ Monaco EA (2004). "Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease". Curr Alzheimer Res 1 (1): 33–8. PMID 15975083.

External links

MeSH Cyclin-Dependent+Kinase+5

Template:Gene-7-stub

[pmid1639063-0] Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. PMID 1639063.

[pmid8275715-1] Demetrick DJ, Zhang H, Beach DH (1994). "Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes". Cytogenet. Cell Genet. 66 (1): 72–4. PMID 8275715.

[pmid10604467-2] Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH (1999). "Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration". Nature 402 (6762): 615–22. doi:10.1038/45159. PMID 10604467.

[pmid11248669-3] Paglini G, Cáceres A (2001). "The role of the Cdk5--p35 kinase in neuronal development". Eur. J. Biochem. 268 (6): 1528–33. doi:10.1046/j.1432-1327.2001.02023.x. PMID 11248669.

[pmid11584302-4] Dhavan R, Tsai LH (2001). "A decade of CDK5". Nat. Rev. Mol. Cell Biol. 2 (10): 749–59. doi:10.1038/35096019. PMID 11584302.

[pmid15975083-5] Monaco EA (2004). "Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease". Curr Alzheimer Res 1 (1): 33–8. PMID 15975083.

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[5]

[6]

v • d • e Cell cycle proteins
Cyclin	A - B - D - E
Cyclin-dependent kinase	2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase
Cyclin-dependent kinase inhibitor protein	p14arf/p16INK4a - p21 - p27 - p57
Other	Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee

Cyclin-dependent kinase 5

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