Cyclin-dependent kinase 8

Cyclin-dependent kinase 8
Identifiers
Symbol(s)	CDK8; K35; MGC126074; MGC126075
External IDs	OMIM: 603184 MGI: 1196224 Homologene: 55565
Gene ontology Molecular Function: • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • ATP binding • transferase activity Cellular Component: • mediator complex • nucleus Biological Process: • regulation of progression through cell cycle • transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • cell cycle • cell division
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1024	264064
Ensembl	ENSG00000132964	ENSMUSG00000029635
Uniprot	P49336	na
Refseq	NM_001260 (mRNA) NP_001251 (protein)	NM_181570 (mRNA) NP_853548 (protein)
Location	Chr 13: 25.73 - 25.88 Mb	Chr 5: 146.54 - 146.61 Mb
Pubmed search	[1]	[2]

Cyclin-dependent kinase 8, also known as CDK8, is a human gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Further reading

• Tassan JP, Jaquenoud M, Léopold P, et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871-5. PMID 7568034.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821-30. PMID 8274451.
• Rickert P, Seghezzi W, Shanahan F, et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.". Oncogene 12 (12): 2631-40. PMID 8700522.
• Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817-23. PMID 9121429.
• Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605-10. PMID 9159119.
• Neish AS, Anderson SF, Schlegel BP, et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme.". Nucleic Acids Res. 26 (3): 847-53. PMID 9443979.
• Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355-63. PMID 9710619.
• Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.". Mol. Cell 2 (2): 213-22. PMID 9734358.
• Rickert P, Corden JL, Lees E (1999). "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases.". Oncogene 18 (4): 1093-102. doi:10.1038/sj.onc.1202399. PMID 10023686.
• Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.". Mol. Cell 3 (1): 97-108. PMID 10024883.
• Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361-70. PMID 10198638.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824-8. doi:10.1038/19783. PMID 10235266.
• Akoulitchev S, Chuikov S, Reinberg D (2000). "TFIIH is negatively regulated by cdk8-containing mediator complexes.". Nature 407 (6800): 102-6. doi:10.1038/35024111. PMID 10993082.
• Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.". J. Biol. Chem. 276 (14): 10913-20. doi:10.1074/jbc.M010975200. PMID 11278802.
• Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of mediator complexes from HeLa cell nuclear extract.". Mol. Cell. Biol. 21 (14): 4604-13. doi:10.1128/MCB.21.14.4604-4613.2001. PMID 11416138.
• Di Pietro C, Rapisarda A, Bonaiuto C, et al. (2001). "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7.". Somat. Cell Mol. Genet. 25 (3): 185-9. PMID 11441538.
• Vogel L, Baratte B, Détivaud L, et al. (2002). "Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein.". Biochim. Biophys. Acta 1589 (2): 219-31. PMID 12007796.
• Crowley TE, Kaine EM, Yoshida M, et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.". Mol. Endocrinol. 16 (8): 1727-37. PMID 12145330.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123-7. doi:10.1074/jbc.C300054200. PMID 12584197.

External links

• MeSH CDK8+protein,+human