TAAR8: Difference between revisions

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{{Infobox_gene}}
 
'''Trace amine-associated receptor 8''' is a [[protein]] that in humans is encoded by the ''TAAR8'' [[gene]].<ref name="pmid11574155">{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 |date=Sep 2001 | pmid = 11574155 | pmc =  | doi =10.1016/S0378-1119(01)00651-5 }}</ref><ref name="pmid15718104">{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 |date=Feb 2005 | pmid = 15718104 | pmc =  | doi = 10.1016/j.ygeno.2004.11.010 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref> In humans, TAAR8 is the only [[trace amine-associated receptor]] that is known to be [[Gi subunit|G<sub>i/o</sub>-coupled]].<ref name="Gi/o">{{cite journal | vauthors = Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H | title = Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile | journal = Int J Mol Sci | volume = 15 | issue = 11 | pages = 20638–55 | year = 2014 | pmid = 25391046 | pmc = 4264187 | doi = 10.3390/ijms151120638 | url = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Trace amine associated receptor 8
| HGNCid = 14964
| Symbol = TAAR8
| AltSymbols =; GPR102; TA5; TAR5; TRAR5
| OMIM = 606927
| ECnumber =
| Homologene = 14242
| MGIid = 2685076
  | GeneAtlas_image1 = PBB_GE_TAAR8_gnf1h01258_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83551
    | Hs_Ensembl = ENSG00000146385
    | Hs_RefseqProtein = NP_444508
    | Hs_RefseqmRNA = NM_053278
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 132915525
    | Hs_GenLoc_end = 132916553
    | Hs_Uniprot = Q969N4
    | Mm_EntrezGene = 215859
    | Mm_Ensembl = ENSMUSG00000050804
    | Mm_RefseqmRNA = NM_001010830
    | Mm_RefseqProtein = NP_001010830
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 23765916
    | Mm_GenLoc_end = 23766950
    | Mm_Uniprot = Q5QD07
  }}
}}
'''Trace amine associated receptor 8''', also known as '''TAAR8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>
| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Borowsky B, Adham N, Jones KA, ''et al.'' |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966-71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 }}
*{{cite journal   |vauthors=Borowsky B, Adham N, Jones KA, etal |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966–71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198  | pmc=55357 }}
*{{cite journal | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lindemann L, Ebeling M, Kratochwil NA, ''et al.'' |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372-85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{TAAR ligands}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]


{{WH}}
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[[Category:G protein-coupled receptors]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 05:13, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.[1][2][3] In humans, TAAR8 is the only trace amine-associated receptor that is known to be Gi/o-coupled.[4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][3]

See also

References

  1. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  2. ↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  3. ↑ 3.0 3.1 "Entrez Gene: TAAR8 trace amine associated receptor 8".
  4. ↑ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H (2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". Int J Mol Sci. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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