Latrophilin: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
(10.1007/978-1-4419-7913-1_5) |
||
| Line 92: | Line 92: | ||
| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
'''Latrophilins''' are a group of highly conserved [[G-protein coupled receptor]]s from the [[adhesion G protein-coupled receptor]] family. These receptors were originally identified based on their ability to bind the spider venom [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal |vauthors=Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite journal|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=The latrophilins, "split-personality" receptors.|journal=Advances in Experimental Medicine and Biology|date=2010|volume=706|pages=59–75|pmid=21618826|pmc=3145135}}</ref> | '''Latrophilins''' are a group of highly conserved [[G-protein coupled receptor]]s from the [[adhesion G protein-coupled receptor]] family. These receptors were originally identified based on their ability to bind the spider venom [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal |vauthors=Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite journal|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=The latrophilins, "split-personality" receptors.|journal=Advances in Experimental Medicine and Biology|date=2010|volume=706|pages=59–75|pmid=21618826|pmc=3145135|doi=10.1007/978-1-4419-7913-1_5}}</ref> | ||
The precise functions of latrophilins remain unknown.<ref name="JPS" /> Genetic defects in latrophilin genes have been associated with diseases such as [[attention-deficit hyperactivity disorder]] and [[cancer]].<ref>{{cite journal|last1=Meza-Aguilar|first1=Diana G|last2=Boucard|first2=Antony A|title=Latrophilins updated|journal=Biomolecular Concepts|date=1 January 2014|volume=5|issue=6|doi=10.1515/bmc-2014-0032}}</ref> | The precise functions of latrophilins remain unknown.<ref name="JPS" /> Genetic defects in latrophilin genes have been associated with diseases such as [[attention-deficit hyperactivity disorder]] and [[cancer]].<ref>{{cite journal|last1=Meza-Aguilar|first1=Diana G|last2=Boucard|first2=Antony A|title=Latrophilins updated|journal=Biomolecular Concepts|date=1 January 2014|volume=5|issue=6|doi=10.1515/bmc-2014-0032}}</ref> | ||
Revision as of 18:27, 12 December 2017
| Latrophilin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Latrophilin | ||||||||
| Pfam | PF02354 | ||||||||
| InterPro | IPR003334 | ||||||||
| |||||||||
| EGF, latrophilin and seven transmembrane domain containing 1 | |
|---|---|
| Identifiers | |
| Symbol | ELTD1 |
| Alt. symbols | ETL |
| Entrez | 64123 |
| HUGO | 20822 |
| RefSeq | NM_022159 |
| UniProt | Q9HBW9 |
| Other data | |
| Locus | Chr. 1 p33-p32 |
| latrophilin 1 | |
|---|---|
| Identifiers | |
| Symbol | LPHN1 |
| Alt. symbols | KIAA0821, CIRL1, LEC2 |
| Entrez | 22859 |
| HUGO | 20973 |
| RefSeq | NM_014921 |
| UniProt | O94910 |
| Other data | |
| Locus | Chr. 19 p13.2 |
| latrophilin 2 | |
|---|---|
| Identifiers | |
| Symbol | LPHN2 |
| Alt. symbols | LPHH1, KIAA0786, LEC1 |
| Entrez | 23266 |
| HUGO | 18582 |
| OMIM | 607018 |
| RefSeq | NM_012302 |
| UniProt | O95490 |
| Other data | |
| Locus | Chr. 1 p31.1 |
| latrophilin 3 | |
|---|---|
| Identifiers | |
| Symbol | LPHN3 |
| Alt. symbols | KIAA0768, LEC3 |
| Entrez | 23284 |
| HUGO | 20974 |
| RefSeq | NM_015236 |
| UniProt | Q9HAR2 |
| Other data | |
| Locus | Chr. 4 q13.1 |
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]
The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]
Human proteins containing this domain
See also
References
- ↑ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
- ↑ 2.0 2.1 Silva, JP; Ushkaryov, YA (2010). "The latrophilins, "split-personality" receptors". Advances in Experimental Medicine and Biology. 706: 59–75. doi:10.1007/978-1-4419-7913-1_5. PMC 3145135. PMID 21618826.
- ↑ Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.