Leukotriene B4 receptor 1

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
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Wikidata
View/Edit Human

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.

See also

• Eicosanoid receptor
• Etalocib, an antagonist at the leukotriene B4 receptor

Further reading

• Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family". J. Leukoc. Biol. 59 (1): 18–23. PMID 8558062.
• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.
• Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation". Allergology International. 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620–4. doi:10.1038/42506. PMID 9177352.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits". Biochem. J. 335 (1): 15–8. PMC 1219746. PMID 9742207.
• Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
• Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230.
• Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival". J. Immunol. 168 (7): 3570–6. doi:10.4049/jimmunol.168.7.3570. PMID 11907121.
• Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128.
• Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue". Am. J. Pathol. 161 (2): 421–8. doi:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367.
• Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116.
• Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor". Adv. Exp. Med. Biol. 507: 357–61. doi:10.1007/978-1-4615-0193-0_55. PMID 12664610.

External links

• "Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• LTB4R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Receptors,+Leukotriene+B4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.