Allobarbital

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Allobarbital
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Synonyms5,5-Diallylbarbituric acid, Allobarbital
ATC code
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E number{{#property:P628}}
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Chemical and physical data
FormulaC10H12N2O3
Molar mass208.214 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Allobarbital, also known as allobarbitone and branded as Cibalgine or Dial-Ciba (in combination with ethyl carbamate), is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant[1] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,[2] and is still used in for example Poland, but only as compound.[3]

References

  1. Chocholova L.; Radil-Weiss, T. (1971). "Effect of allobarbital on focal epilepsy in rats". Physiologia Bohemoslovaca. 20 (4): 325–34. PMID 4335127.
  2. Getova, D.; Georgiev, V. (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists". Acta Physiologica et Pharmacologica Bulgarica. 13 (3): 43–50. PMID 3439474.
  3. "APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G". Domzdrowia.pl (in Polish). Archived from the original on October 31, 2007. Retrieved March 10, 2013. Unknown parameter |trans_title= ignored (help)

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