Chlorphenesin

Jump to: navigation, search
Chlorphenesin
Chlorphenesin.png
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
Excretionurine
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC10H12ClNO4
Molar mass245.660 g/mol
3D model (JSmol)
Melting point86 to 92 °C (Expression error: Unrecognized word "to". °F)

WikiDoc Resources for Chlorphenesin

Articles

Most recent articles on Chlorphenesin

Most cited articles on Chlorphenesin

Review articles on Chlorphenesin

Articles on Chlorphenesin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Chlorphenesin

Images of Chlorphenesin

Photos of Chlorphenesin

Podcasts & MP3s on Chlorphenesin

Videos on Chlorphenesin

Evidence Based Medicine

Cochrane Collaboration on Chlorphenesin

Bandolier on Chlorphenesin

TRIP on Chlorphenesin

Clinical Trials

Ongoing Trials on Chlorphenesin at Clinical Trials.gov

Trial results on Chlorphenesin

Clinical Trials on Chlorphenesin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Chlorphenesin

NICE Guidance on Chlorphenesin

NHS PRODIGY Guidance

FDA on Chlorphenesin

CDC on Chlorphenesin

Books

Books on Chlorphenesin

News

Chlorphenesin in the news

Be alerted to news on Chlorphenesin

News trends on Chlorphenesin

Commentary

Blogs on Chlorphenesin

Definitions

Definitions of Chlorphenesin

Patient Resources / Community

Patient resources on Chlorphenesin

Discussion groups on Chlorphenesin

Patient Handouts on Chlorphenesin

Directions to Hospitals Treating Chlorphenesin

Risk calculators and risk factors for Chlorphenesin

Healthcare Provider Resources

Symptoms of Chlorphenesin

Causes & Risk Factors for Chlorphenesin

Diagnostic studies for Chlorphenesin

Treatment of Chlorphenesin

Continuing Medical Education (CME)

CME Programs on Chlorphenesin

International

Chlorphenesin en Espanol

Chlorphenesin en Francais

Business

Chlorphenesin in the Marketplace

Patents on Chlorphenesin

Experimental / Informatics

List of terms related to Chlorphenesin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chlorphenesin (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.[1][2] Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.

Other central effects include sedation, anxiolysis, and dizziness. It also has antifungal and some antibacterial properties and is thus classified as an antifungal for topical use by the WHO.[3]

Safety

The major adverse effect from this preservative on skin is allergic contact sensitivity.[4][5] Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.[6]

References

  1. Okuyama, S; Aihara, H (1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research communications in chemical pathology and pharmacology. 55 (2): 147–60. PMID 3823606.
  2. Kurachi, M; Aihara, H (1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese journal of pharmacology. 36 (1): 7–13. doi:10.1254/jjp.36.7. PMID 6503049.
  3. ATC code D01AE07
  4. Brown R (1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118.
  5. Burns DA (1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (33): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223.
  6. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116900.htm. Missing or empty |title= (help)

Linked-in.jpg