Suriclone

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Suriclone
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Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC20H20ClN5O3S2
Molar mass477.988 g/mol


Suriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone.

Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects,[1][2] and its chemical structure is quite different to that of the benzodiazepine drugs.

The mechanism of action by which suriclone produces its sedative and anxiolytic effects is by modulating GABAA receptors, although suriclone is more subtype-selective than most benzodiazepines.[3]

References

  1. Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundamental and Clinical Pharmacology. 1992;6(6):251-8.
  2. Saletu B, Grunberger J, Linzmayer L, Semlitsch HV, Anderer P, Chwatal K. Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry. British Journal of Clinical Pharmacology. 1994 Feb;37(2):145-56.
  3. Blanchard JC (1983). "Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum". J Neurochem. 40 (3): 601–7. PMID 6298365. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)



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