Talbutal

Jump to: navigation, search
Talbutal
Talbutal.png
Clinical data
Synonyms5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC11H16N2O3
Molar mass224.256 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Talbutal

Articles

Most recent articles on Talbutal

Most cited articles on Talbutal

Review articles on Talbutal

Articles on Talbutal in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Talbutal

Images of Talbutal

Photos of Talbutal

Podcasts & MP3s on Talbutal

Videos on Talbutal

Evidence Based Medicine

Cochrane Collaboration on Talbutal

Bandolier on Talbutal

TRIP on Talbutal

Clinical Trials

Ongoing Trials on Talbutal at Clinical Trials.gov

Trial results on Talbutal

Clinical Trials on Talbutal at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Talbutal

NICE Guidance on Talbutal

NHS PRODIGY Guidance

FDA on Talbutal

CDC on Talbutal

Books

Books on Talbutal

News

Talbutal in the news

Be alerted to news on Talbutal

News trends on Talbutal

Commentary

Blogs on Talbutal

Definitions

Definitions of Talbutal

Patient Resources / Community

Patient resources on Talbutal

Discussion groups on Talbutal

Patient Handouts on Talbutal

Directions to Hospitals Treating Talbutal

Risk calculators and risk factors for Talbutal

Healthcare Provider Resources

Symptoms of Talbutal

Causes & Risk Factors for Talbutal

Diagnostic studies for Talbutal

Treatment of Talbutal

Continuing Medical Education (CME)

CME Programs on Talbutal

International

Talbutal en Espanol

Talbutal en Francais

Business

Talbutal in the Marketplace

Patents on Talbutal

Experimental / Informatics

List of terms related to Talbutal

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.

Pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.[1]

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl ionopore at the GABAA receptor, increasing the duration of time for which the Cl ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,[1] and shock.

References

  1. 1.0 1.1 Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2.



Linked-in.jpg