Pancytopenia

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Pancytopenia Classification and external resources
ICD-10	D61.0, R79.1
ICD-9	284.0, 284.8

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Pancytopenia is the pronounced reduction in the number of erythrocytes, all types of white blood cells and blood platelets that are circulating in the blood. ^[1]

Pancytopenia is generally due to diseases affecting the bone marrow, although peripheral destruction of all lines of blood cells in hypersplenism (overactive spleen) is a recognized cause. Bone marrow problems causing pancytopenia include myelofibrosis, leukemia, aplastic anemia, and the malignant form of osteoporosis.

Chemotherapy for malignancies may also cause pancytopenia, if the drug or drugs used cause bone marrow suppression.

Increasingly, HIV (Human Immunodeficiency Virus) is itself a cause for pancytopenia. Rarely, drugs (antibiotics, anti hypertensive medication, heart medication) can cause pancytopenia.

Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.

Causes of pancytopenia

1. Aplastic anemia
2. Myelodysplastic syndrome
3. Leukemia
4. Leishmaniasis
5. Severe Folate or Vitamin B12 deficiency
6. Paroxysmal nocturnal hemoglobinuria (Urine test)
7. Finally overwhelming viral infections (HIV most common).

Differential Diagnosis

Congenital

• Cartilage hair hypoplasia
• Diamond-Blackfan syndrome
• Dubowitz syndrome
• Dyskeratosis congenita
• Familial aplastic anemia
• Fanconi's anemia
• Pearson syndrome
• Schwachman-Diamond syndrome
• TAR syndrome

Acquired

• Albers-Schonberg disease
• Banti's Syndrome
• Bone marrow tumor
• Cirrhosis
• Drugs/Toxins
• Felty's Syndrome
• Gaucher's Disease
• Graft-versus-host disease
• Infections
• Kala-Azar
• Leukemia
• Lymphoma
• Lymphoproliferative Disorders
• Myelodysplastic syndrome
• Myelofibrosis
• Niemann-Pick Disease
• Osteoporosis
• Pernicious anemia
• Reticulosis
• Sarcoidosis
• Thymoma
• Tuberculosis

References

See also

• Leukopenia, a reduction in white blood cells
• Neutropenia, a reduction in neutrophil granulocytes

Acknowledgements

The content on this page was first contributed by Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Phone:617-525-6884

List of contributors:

Suggested Reading and Key General References

Suggested Links and Web Resources

For Patients

v • d • e WikiDoc Research Resources for Pancytopenia (Click show to right to view)
Articles on Pancytopenia	Most recent articles on Pancytopenia • Most cited articles on Pancytopenia • Review articles on Pancytopenia • Articles on Pancytopenia in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Pancytopenia	Powerpoint slides on Pancytopenia • Images of Pancytopenia • Photos of Pancytopenia • Podcasts & MP3s on Pancytopenia • Videos on Pancytopenia
Evidence Based Medicine Regarding Pancytopenia	Cochrane Collaboration on Pancytopenia • Bandolier on Pancytopenia • TRIP on Pancytopenia
Cost Effectiveness of Pancytopenia	Cost Effectiveness of Pancytopenia
Clinical Trials Involving Pancytopenia	Ongoing Trials on Pancytopenia at Clinical Trials.gov • Trial results on Pancytopenia • Clinical Trials on Pancytopenia at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Pancytopenia	US National Guidelines Clearinghouse on Pancytopenia • NICE Guidance on Pancytopenia • NHS PRODIGY Guidance • FDA on Pancytopenia • CDC on Pancytopenia
Textbook Information on Pancytopenia	Books and Textbook Information on Pancytopenia
Pharmacology Resources on Pancytopenia	Dosing of Pancytopenia • Drug interactions with Pancytopenia • Side effects of Pancytopenia • Allergic reactions to Pancytopenia • Overdose information on Pancytopenia • Carcinogenicity information on Pancytopenia • Pancytopenia in pregnancy • Pharmacokinetics of Pancytopenia •
Genetics, Pharmacogenomics, and Proteinomics of Pancytopenia	Genetics of Pancytopenia • Pharmacogenomics of Pancytopenia • Proteomics of Pancytopenia
Newstories on Pancytopenia	Pancytopenia in the news • Be alerted to news on Pancytopenia • News trends on Pancytopenia
Commentary on Pancytopenia	Blogs on Pancytopenia
Patient Resources on Pancytopenia	Patient resources on Pancytopenia • Discussion groups on Pancytopenia • Patient Handouts on Pancytopenia • Directions to Hospitals Treating Pancytopenia • Risk calculators and risk factors for Pancytopenia
Healthcare Provider Resources on Pancytopenia	Symptoms of Pancytopenia • Causes & Risk Factors for Pancytopenia • Diagnostic studies for Pancytopenia • Treatment of Pancytopenia
Continuing Medical Education (CME) Programs on Pancytopenia	CME Programs on Pancytopenia
International Resources on Pancytopenia	Pancytopenia en Espanol • Pancytopenia en Francais
Business Resources on Pancytopenia	Pancytopenia in the Marketplace • Patents on Pancytopenia
Informatics Resources on Pancytopenia	List of terms related to Pancytopenia

fr:Pancytopénie ja:汎血球減少

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .