Autoimmune hemolytic anemia
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| Autoimmune hemolytic anemia Classification and external resources | |
| ICD-10 | D59.0-D59.1 |
|---|---|
| ICD-9 | 283.0 |
| MeSH | D000744 |
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Overview
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis). Antibodies and associated complement system components become fixed onto the RBC surface. These antibodies can be detected with the direct antiglobulin test, also known as the direct Coombs test. AIHA can also be induced by several drugs including methyl-dopa and fluarabine.
Autoimmunity must not be confused with alloimmunity.
Classification
Haemolysis can be intravascular or extravascular.
Intravascular haemolysis
Red blood cell lysis occurs in the circulation as a result of activation of the complement system cascade.
Extravascular haemolysis
Red Blood Cells that are coated with antibodies are specifically recognised in the reticuloendothelial system and destroyed by macrophages.
Subtypes
Warm antibody autoimmune hemolytic anemia
- Idiopathic
- Systemic lupus erythematosus
- Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
- Chronic lymphocytic leukemia
- Drugs (methyldopa)
Cold antibody autoimmune hemolytic anemia
- Idiopathic cold hemagglutinin syndrome
- Infectious mononucleosis
- Paroxysmal cold hemoglobinuria (rare)
- Lymphoma
Mixed-type autoimmune hemolytic anemia
Laboratory findings
- Positive direct Coombs test
- Anaemia
See also
References
External links
- Case report of Autoimmune Hemolytic Anemia with typical laboratory findings. Clinical Cases and Images.
WikiDoc Research Resources for Autoimmune hemolytic anemia | |
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| Articles on Autoimmune hemolytic anemia | Most recent articles on Autoimmune hemolytic anemia • Most cited articles on Autoimmune hemolytic anemia • Review articles on Autoimmune hemolytic anemia • Articles on Autoimmune hemolytic anemia in N Eng J Med, Lancet, BMJ |
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| Evidence Based Medicine Regarding Autoimmune hemolytic anemia | Cochrane Collaboration on Autoimmune hemolytic anemia • Bandolier on Autoimmune hemolytic anemia • TRIP on Autoimmune hemolytic anemia |
| Cost Effectiveness of Autoimmune hemolytic anemia | Cost Effectiveness of Autoimmune hemolytic anemia |
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| Genetics, Pharmacogenomics, and Proteinomics of Autoimmune hemolytic anemia | Genetics of Autoimmune hemolytic anemia • Pharmacogenomics of Autoimmune hemolytic anemia • Proteomics of Autoimmune hemolytic anemia |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
