Hepato-biliary diseases

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Articles on Hepato-biliary diseases in N Eng J Med, Lancet, BMJ


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Ongoing Trials on Hepato-biliary diseases at Clinical Trials.gov

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US National Guidelines Clearinghouse on Hepato-biliary diseases

NICE Guidance on Hepato-biliary diseases


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Risk calculators and risk factors for Hepato-biliary diseases

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Symptoms of Hepato-biliary diseases

Causes & Risk Factors for Hepato-biliary diseases

Diagnostic studies for Hepato-biliary diseases

Treatment of Hepato-biliary diseases

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Hepato-biliary diseases en Espanol

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Experimental / Informatics

List of terms related to Hepato-biliary diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

For the approach to a patient with liver disease, please click here.

Normal Liver

View of Liver from the top View of Liver from the bottom

Histopathological Findings of a Normal Liver

Viral hepatitis

Histopathological Findings in Viral hepatitis

Histopathological Findings in Viral hepatitis with Fulminant Necrosis

Liver Dysfunction in other Infectious Diseases [1] [2]

Other Inflammatory Liver Diseases

Alcoholic liver disease

This may cause fatty liver, hepatitis, fibrosis and sclerosis leading to cirrhosis and finally hepatic failure.

Histopathological Findings of Alcoholic Liver Disease

Toxic Liver Disease

This includes mostly drug-induced hepatotoxicity, which may generate many different patterns over liver disease, including;

Liver damage is part of Reye's syndrome.

Histopathological Findings: Liver: Centrilobular Necrosis from Chloroform

Liver tumors

Malignant neoplasm of liver and intrahepatic bile ducts. The most frequent forms are metastatic malignant neoplasm of liver)

Benign neoplasm of liver include hepatic hemangiomas, hepatic adenomas, and focal nodular hyperplasia (FNH).

End-stage liver disease

Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or chronic toxic liver disease may cause

Cirrhosis may also occur in primary biliary cirrhosis. Rarely, cirrhosis is congenital.

Metabolic diseases (Chapter E in ICD-10)

Vascular Disorders



Amyloid degeneration of liver

Gallbladder and biliary tract diseases


In hepatology, important signs and symptoms include:

Complete Differential Diagnosis of Causes of Hepato-biliary diseases

Autoimmune, Systemic



Liver Changes





Active liver disease is considered an absolute contraindication to the use of the following medications:

Marked liver dysfunction is considered an absolute contraindication to the use of the following medications:

Liver dysfunction is considered an absolute contraindication to the use of the following medications:

Histopathological Findings in Liver Diseases

Liver: Cryptococcosis

Liver: Cytomegalic inclusion disease

Liver: Echinococcus cyst

Liver: Histoplasmosis

Liver & Spleen in Malaria

Liver: Alpha-1-antitrypsin deficiency

Liver: Cardiac sclerosis (cardiac cirrhosis)

Liver: Centrilobular necrosis from chloroform

Liver: Chronic active hepatitis, cirrhosis

Liver: Cirrhosis (micronodular)

Liver: Congenital cytomegalovirus disease

Liver: Erythroblastosis fetalis

Fulminant hepatitis (massive hepatic necrosis)

Liver: Hepatitis, yellow fever virus

Herpes hepatitis

Liver: Traumatic hemorrhage

Liver: Viral hepatitis

Liver: Viral hepatitis with fulminant necrosis

Fulminant hepatitis (massive hepatic necrosis) is an acute liver failure (<1 month) resulting in rapid hepatic compensation characterized by synthetic dysfunction (hypoglycemia, coagulopathy), coma (cerebral edema, hepatic encephalopathy) and associated with infectious, renal, pulmonary and metabolic complications.

Active liver disease is considered an absolute contraindication to the use of the following medications:

Liver: Wilson disease


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X