Myelophthisis

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Synonyms: Myelophthisic anemia

Overview

Myelophthisis refers to the displacement of hemopoietic bone-marrow tissue into the peripheral blood, either by fibrosis, tumors or granulomas. A myelophthisic blood smear is one which contains nucleated red blood cells, granulocyte precursors, and teardrop-shaped erythrocytes. This condition is also known as Myelophthisic anemia. Myelophthisis can be observed in cancers that that involve the bone marrow such as leukemia, lymphoma, and myeloma or metastatic carcinoma. The commonest cause is metastatic cancer, most often carcinomas arising in breast, lung and prostate.However any infiltrative process (e.g.,granulomatous disease) involving the marrow can produce identical findings.It should be remembered that it is also a feature of spent phase of myeloproliferative disorders.They cause marrow distortion and fibrosis which act to displace normal marrow elements and disturb mechanisms that regulate the egress of red cells and granulocytes from the marrow.

Cost Effectiveness of Myelophthisis

| group5 = Clinical Trials Involving Myelophthisis | list5 = Ongoing Trials on Myelophthisis at Clinical Trials.gov • Trial results on Myelophthisis • Clinical Trials on Myelophthisis at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Myelophthisis | list6 = US National Guidelines Clearinghouse on Myelophthisis • NICE Guidance on Myelophthisis • NHS PRODIGY Guidance • FDA on Myelophthisis • CDC on Myelophthisis

| group7 = Textbook Information on Myelophthisis | list7 = Books and Textbook Information on Myelophthisis

| group8 = Pharmacology Resources on Myelophthisis | list8 = AND (Dose)}} Dosing of Myelophthisis • AND (drug interactions)}} Drug interactions with Myelophthisis • AND (side effects)}} Side effects of Myelophthisis • AND (Allergy)}} Allergic reactions to Myelophthisis • AND (overdose)}} Overdose information on Myelophthisis • AND (carcinogenicity)}} Carcinogenicity information on Myelophthisis • AND (pregnancy)}} Myelophthisis in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Myelophthisis •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Myelophthisis | list9 = AND (pharmacogenomics)}} Genetics of Myelophthisis • AND (pharmacogenomics)}} Pharmacogenomics of Myelophthisis • AND (proteomics)}} Proteomics of Myelophthisis

| group10 = Newstories on Myelophthisis | list10 = Myelophthisis in the news • Be alerted to news on Myelophthisis • News trends on Myelophthisis</small>

| group11 = Commentary on Myelophthisis | list11 = Blogs on Myelophthisis

| group12 = Patient Resources on Myelophthisis | list12 = Patient resources on Myelophthisis • Discussion groups on Myelophthisis • Patient Handouts on Myelophthisis • Directions to Hospitals Treating Myelophthisis • Risk calculators and risk factors for Myelophthisis

| group13 = Healthcare Provider Resources on Myelophthisis | list13 = Symptoms of Myelophthisis • Causes & Risk Factors for Myelophthisis • Diagnostic studies for Myelophthisis • Treatment of Myelophthisis

| group14 = Continuing Medical Education (CME) Programs on Myelophthisis | list14 = CME Programs on Myelophthisis

| group15 = International Resources on Myelophthisis | list15 = Myelophthisis en Espanol • Myelophthisis en Francais

| group16 = Business Resources on Myelophthisis | list16 = Myelophthisis in the Marketplace • Patents on Myelophthisis

| group17 = Informatics Resources on Myelophthisis | list17 = List of terms related to Myelophthisis

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