Nicotine
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Synonyms: L-Nicotine, Nicotine Alkaloid.
Brand Names: Black Leaf, Black Leaf 40, Campbell's Nico-Soap, Commit, Destruxol Orchid Spray, Emo-Nik, Flux Maag, Fumetobac, Habitrol, Mach-Nic, Niagara P.A. Dust, Nic-Sal, Nico-Dust, Nico-Fume, Nicocide, Nicoderm, Nicoderm Cq, Nicorette, Nicorette Plus, Nicotin, Nicotina, Nicotine Polacrilex, Nicotrol, Nicotrol Inhaler, Nicotrol Ns, Nikotin, Nikotyna, Ortho N-4 Dust, Ortho N-5 Dust, Prostep, Tendust.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Dosing and Administration
Advise patient to stop smoking completely when beginning to use smoking cessation therapy.
Nicotine gum
Adults: PO If patient smokes less than 25 cigarettes/day, chew 2 mg gum (max, 24 pieces/day) for up to 12 wk. If patient smokes at least 25 cigarettes/day, chew 4 mg gum (max, 24 pieces/day) for up to 12 wk.
Nicotine lozenges
Adults: PO If patient smokes first cigarette more than 30 min after waking up, start with the 2 mg lozenge. If patient smokes first cigarette within 30 min after waking up, start with the 4 mg lozenge. Week 1 to 6, slowly dissolve 1 lozenge in the mouth every 1 to 2 h; week 7 to 9, slowly dissolve 1 lozenge in the mouth every 2 to 4 h; week 10 to 12, slowly dissolve 1 lozenge in the mouth every 4 to 8 h.
Nicotine inhaler
Adults: Inhaler 6 to 16 cartridges/day for up to 6 mo.
Nicotine transdermal patches
Adults Habitrol: Topical If patient smokes at least 10 cigarettes/day, start with 21 mg/day for first 4 wk, then decrease dose to 14 mg/day for next 2 wk, then decrease dose to 7 mg/day for last 2 wk. If patient smokes less than 10 cigarettes/day, start with 14 mg/day for 6 wk then decrease dose to 7 mg/day for last 2 wk.
Nicoderm
Topical If patient smokes at least 10 cigarettes/day, start with 21 mg/day for first 6 wk then decrease dose to 14 mg/day for next 2 wk, then decrease dose to 7 mg/day for last 2 wk. If patient smokes less than 10 cigarettes/day, start with 14 mg/day for 6 wk then decrease dose to 7 mg/day for last 2 wk.
Nicotrol
Topical Use 15 mg/16 h for 6 wk.
Nicotine nasal spray
Adults: Spray (Each actuation delivers 50 mcL spray containing 0.5 mg nicotine.) 8 to 40 doses/day for 3 to 6 mo.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Nicotine
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Publication Resources
Most Recent Articles on Nicotine
Review Articles on Nicotine
Articles on Nicotine in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Nicotine
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Trial Resources
Ongoing Trials with Nicotine at Clinical Trials.gov
Trial Results with Nicotine
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Nicotine
Cochrane Collaboration on Nicotine
Cost Effectiveness of Nicotine
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Media Resources
Powerpoint Slides on Nicotine
Images of Nicotine
Podcasts & MP3s on Nicotine
Videos on Nicotine
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Nicotine
Discussion Groups on Nicotine
Patient Handouts on Nicotine
Blogs on Nicotine
Nicotine in the News
Nicotine in the Marketplace
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International Resources
Nicotine en Español
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The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
