Enflurane
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| Image:Enflurane2.png | |
| Image:Enflurane-3D-balls.png | |
| Enflurane
| |
| Systematic (IUPAC) name | |
| 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C3H2ClF5O |
| Mol. mass | 184.492 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 97% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.
Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.
Physical properties
| Property | Value |
|---|---|
| Boiling point at 1 atm | 56.5 °C |
| MAC | 1.68 |
| Vapor pressure at 20 °C | 22.9 kPa (172 mm Hg) |
| Blood: Gas Partition Coefficient | 1.9 |
| Oil: Gas Partition Coefficient | 98 |
Side Effects
Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.
Enflurane also lowers the threshold for seizures and should especially not be used on people with epilepsy. It is also known to cause malignant hyperthermia.
External links
de:Enfluranfr:Enflurane it:Enflurano nl:Enfluraan
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
