CYP17A1

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cytochrome P450, family 17, subfamily A, polypeptide 1
Identifiers
Symbol	CYP17A1
Alt. Symbols	CYP17
Entrez	1586
HUGO	2593
OMIM	609300
RefSeq	NM_000102
UniProt	P05093
Other data
EC number	1.14.99.9
Locus	Chr. 10 q24.3

CYP17A1 (also known as 17α-hydroxylase/17,20 lyase) is a cytochrome P450 enzyme which acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 of the steroid D ring (the hydroxylase activity), or acts upon 17-hydroxyprogesterone and 17-hydroxypregnenolone to split the side chain off the steroid nucleus (the lyase activity).

17α-hydroxylase converts pregnenolone and progesterone to their 17-hydroxy forms, and converts 17-hydroxypregnenolone and 17-hydroxyprogesterone to DHEA and androstenedione, respectively. It corresponds to the downward arrows in this reaction scheme.

Additional images

Pregnenolone
17-Hydroxypregnenolone.png

17-Hydroxypregnenolone
Progesterone
17-Hydroxyprogesterone.png

17-Hydroxyprogesterone
Steroidogenesis
Steroid numbering

External links

MeSH CYP17A1+protein,+human

v • d • e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarate	Prolyl hydroxylase - Lysyl hydroxylase
1.14.13 - NADH or NADPH	Flavin-containing monooxygenase - Nitric oxide synthase - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1
1.14.14 - reduced flavin or flavoprotein	19A1 - 2D6 - 2E1
1.14.15 - reduced iron-sulfur protein	11B1 - 11B2 - 11A1
1.14.16 - reduced pteridine	Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase
1.14.17 - reduced ascorbate	Dopamine beta hydroxylase
1.14.18-19 - other	Tyrosinase - Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2

Template:Steroid hydroxylases

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14)
CYP1	A1, A2, B1
CYP2	A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1
CYP3	A4, A5, A7, A43
CYP4	A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1
CYP5-20	CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1)
CYP21-51	CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)