CYP2E1

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Cytochrome P450, family 2, subfamily E, polypeptide 1
Identifiers
Symbol(s)	CYP2E1; CPE1; CYP2E; P450-J; P450C2E
External IDs	OMIM: 124040 MGI: 88607 Homologene: 68089
Gene ontology Molecular Function: • monooxygenase activity • iron ion binding • oxygen binding • heme binding • metal ion binding • unspecific monooxygenase activity Cellular Component: • endoplasmic reticulum • microsome • membrane Biological Process: • electron transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1571	13106
Ensembl	ENSG00000130649	ENSMUSG00000025479
Uniprot	P05181	Q05421
Refseq	NM_000773 (mRNA) NP_000764 (protein)	NM_021282 (mRNA) NP_067257 (protein)
Location	Chr 10: 135.19 - 135.22 Mb	Chr 7: 140.62 - 140.63 Mb
Pubmed search	[1]	[2]

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List of terms related to CYP2E1

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.

CYP2E1 Ligands

Selected inducers, inhibitors and substrates of CYP2E1

Substrates	Inhibitors	Inducers
Often mentioned: anaesthetics halothane isoflurane enflurane paracetamol (analgesic, antipyretic) Other: dapsone (antibiotic) theophylline (stimulant) ethanol (psychoactive) chlorzoxazone (muscle relaxant) toluene (solvent) - primarily	Strong: diethyldithiocarbamate (in cancer) unspecified: cimetidine (H2-receptor antagonist) disulfiram (in alcoholism)	acetone (cleaning fluid) ethanol (psychoactive) isoniazid (in tuberculosis)

Regulation of CYP2E1

Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transcriptional induction at high levels of ethanol

See also

• cytochrome
• metabolism

Further reading

• Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. PMID 9890157.
• Kessova I, Cederbaum AI (2003). "CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury". Curr. Mol. Med. 3 (6): 509–18. doi:10.2174/1566524033479609. PMID 14527082.