CYP1A2

Cytochrome P450, family 1, subfamily A, polypeptide 2
PDB rendering based on 2hi4.
Identifiers
Symbol(s)	CYP1A2; CP12; P3-450; P450(PA)
External IDs	OMIM: 124060 MGI: 88589 Homologene: 68082
Gene ontology Molecular Function: • iron ion binding • electron carrier activity • oxygen binding • heme binding • metal ion binding • unspecific monooxygenase activity Cellular Component: • endoplasmic reticulum • microsome • membrane Biological Process: • electron transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1544	13077
Ensembl	ENSG00000140505	ENSMUSG00000032310
Uniprot	P05177	P00186
Refseq	NM_000761 (mRNA) NP_000752 (protein)	NM_009993 (mRNA) NP_034123 (protein)
Location	Chr 15: 72.83 - 72.84 Mb	Chr 9: 57.48 - 57.48 Mb
Pubmed search	[1]	[2]

WikiDoc Resources for CYP1A2
Articles
Most recent articles on CYP1A2 Most cited articles on CYP1A2 Review articles on CYP1A2 Articles on CYP1A2 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on CYP1A2 Images of CYP1A2 Photos of CYP1A2 Podcasts & MP3s on CYP1A2 Videos on CYP1A2
Evidence Based Medicine
Cochrane Collaboration on CYP1A2 Bandolier on CYP1A2 TRIP on CYP1A2
Clinical Trials
Ongoing Trials on CYP1A2 at Clinical Trials.gov Trial results on CYP1A2 Clinical Trials on CYP1A2 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on CYP1A2 NICE Guidance on CYP1A2 NHS PRODIGY Guidance FDA on CYP1A2 CDC on CYP1A2
Books
Books on CYP1A2
News
CYP1A2 in the news Be alerted to news on CYP1A2 News trends on CYP1A2
Commentary
Blogs on CYP1A2
Definitions
Definitions of CYP1A2
Patient Resources / Community
Patient resources on CYP1A2 Discussion groups on CYP1A2 Patient Handouts on CYP1A2 Directions to Hospitals Treating CYP1A2 Risk calculators and risk factors for CYP1A2
Healthcare Provider Resources
Symptoms of CYP1A2 Causes & Risk Factors for CYP1A2 Diagnostic studies for CYP1A2 Treatment of CYP1A2
Continuing Medical Education (CME)
CME Programs on CYP1A2
International
CYP1A2 en Espanol CYP1A2 en Francais
Business
CYP1A2 in the Marketplace Patents on CYP1A2
Experimental / Informatics
List of terms related to CYP1A2

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

Expression of CYP1A2 appears to be induced by various dietary constituents.

CYP1A2 Ligands

Table of selected substrates, inducers and inhibitors of CYP1A2¹

Substrates	Inhibitors	Inducers
Often mentioned : some Antidepressants Amitriptyline (tricyclic antidepressant) Imipramine (antidepressant) Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic) Caffeine (stimulant) Olanzapine (atypical antipsychotic) Ropivacaine (local anaesthetic) Theophylline (Xanthine) Zolmitriptan (Serotonin receptor agonist) Other: cyclobenzaprine (muscle relaxant, depressant) estradiol (in hypoestrogenism) fluvoxamine (SSRI antidepressant) haloperidol (Typical antipsychotic) ondansetron (5-HT3 antagonist) mexiletine (Antiarrhythmic agent) Melatonin (antioxidant, sleep-inducer) Tamoxifen (SERM) naproxen (NSAID) paracetamol (analgesic, antipyretic) phenacetin (analgesic) propranolol (beta blocker) riluzole (in amyotrophic lateral sclerosis) tacrine (parasympathomimetic) tizanidine (α-2 adrenergic agonist) Verapamil (calcium channel blocker) warfarin (anticoagulant) zileuton (in asthma) lidocaine (local anesthetic, antiarrhythmic)	Strong : Ciprofloxacin (fluoroquinolone bactericidal) Many other fluoroquinolones (broad-spectrum antibiotics) Fluvoxamine (SSRI antidepressant) Verapamil (calcium channel blocker) unspecified: amiodarone (antiarrhythmic agent) cimetidine (H2-receptor antagonist) furafylline interferon (antiviral, antiseptic, antioncogenic) methoxsalen (in psoriasis) caffeine (stimulant) echinacea (Immunostimulator) enoxacin (antibacterial ) mexiletine (Antiarrhythmic agent) hormonal contraception zileuton (in asthma)	Often mentioned: tobacco Other: Some foods grapefruit juice (its bitter flavanone naringenin) broccoli brussel sprouts chargrilled meat insulin (in diabetes) modafinil (eugeroic) nafcillin (beta-lactam antibiotic) omeprazole (proton pump inhibitor) hyperforin (constituent of St Johns Wort) (antidepressant) carbamazepine (anticonvulsant) phenobarbital (anticonvulsant) rifampicin (bactericidal)

References

• Meijerman I, Beijnen J, Schellens J. "Herb-drug interactions in oncology: focus on mechanisms of induction". Oncologist 11 (7): 742-52. PMID 16880233.

Further reading

• Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
• Landi MT, Sinha R, Lang NP, Kadlubar FF (1999). "Human cytochrome P4501A2.". IARC Sci. Publ. (148): 173-95. PMID 10493258.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1-18. PMID 15128046.
• Ikeya K, Jaiswal AK, Owens RA, et al. (1990). "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.". Mol. Endocrinol. 3 (9): 1399-408. PMID 2575218.
• Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989). "Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7696-700. PMID 2813353.
• Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH (1986). "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.". DNA 4 (5): 395-400. PMID 3000715.
• Quattrochi LC, Pendurthi UR, Okino ST, et al. (1986). "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6731-5. PMID 3462722.
• Wrighton SA, Campanile C, Thomas PE, et al. (1986). "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.". Mol. Pharmacol. 29 (4): 405-10. PMID 3517618.
• Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1988). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.". J. Exp. Pathol. 3 (1): 1-17. PMID 3681487.
• Jaiswal AK, Nebert DW, Gonzalez FJ (1986). "Human P3(450): cDNA and complete amino acid sequence.". Nucleic Acids Res. 14 (16): 6773-4. PMID 3755823.
• Eugster HP, Probst M, Würgler FE, Sengstag C (1993). "Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.". Drug Metab. Dispos. 21 (1): 43-9. PMID 8095225.
• Schweikl H, Taylor JA, Kitareewan S, et al. (1994). "Expression of CYP1A1 and CYP1A2 genes in human liver.". Pharmacogenetics 3 (5): 239-49. PMID 8287062.
• Yamazaki H, Inoue K, Mimura M, et al. (1996). "7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.". Biochem. Pharmacol. 51 (3): 313-9. PMID 8573198.
• Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.". Biochem. Pharmacol. 52 (2): 379-83. PMID 8694864.
• Guengerich FP, Johnson WW (1998). "Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.". Biochemistry 36 (48): 14741-50. doi:10.1021/bi9719399. PMID 9398194.
• Wacke R, Kirchner A, Prall F, et al. (1998). "Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.". Pancreas 16 (4): 521-8. PMID 9598815.
• Macé K, Bowman ED, Vautravers P, et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.". Eur. J. Cancer 34 (6): 914-20. PMID 9797707.
• Huang JD, Guo WC, Lai MD, et al. (1999). "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.". Drug Metab. Dispos. 27 (1): 98-101. PMID 9884316.
• Tatemichi M, Nomura S, Ogura T, et al. (1999). "Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.". Cancer Res. 59 (16): 3893-8. PMID 10463577.

See also

• Cytochrome P450 oxidase