CYP39A1
| cytochrome P450, family 39, subfamily A, polypeptide 1
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| Identifiers | |
| Symbol | CYP39A1 |
| Entrez | 51302 |
| HUGO | 17449 |
| OMIM | 605994 |
| RefSeq | NM_016593 |
| UniProt | Q9NYL5 |
| Other data | |
| EC number | 1.14.13.99 |
| Locus | Chr. 6 p21.1-11.2 |
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CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1) also known as oxysterol 7-α-hydroxylase 2 is a protein which in humans is encoded by the CYP39A1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol.[2]
References
- ↑ Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". J. Biol. Chem. 275 (22): 16543–9. doi:10.1074/jbc.M001810200. PMID 10748047.
- ↑ Entrez Gene: CYP39A1.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Cytochromes, oxygenases: cytochrome P450 (EC 1.14) | |
|---|---|
| CYP1 | A1, A2, B1 |
| CYP2 | A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 |
| CYP3 | A4, A5, A7, A43 |
| CYP4 | A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 |
| CYP5-20 | CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) |
| CYP21-51 | CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1) |
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