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The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
|1.14.11 - 2-oxoglutarate||Prolyl hydroxylase - Lysyl hydroxylase|
|1.14.13 - NADH or NADPH||Flavin-containing monooxygenase - Nitric oxide synthase - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1|
|1.14.14 - reduced flavin or flavoprotein||19A1 - 2D6 - 2E1|
|1.14.15 - reduced iron-sulfur protein||11B1 - 11B2 - 11A1|
|1.14.16 - reduced pteridine||Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase|
|1.14.17 - reduced ascorbate||Dopamine beta hydroxylase|
|1.14.18-19 - other||Tyrosinase - Stearoyl-CoA desaturase-1|
|1.14.99 - miscellaneous||Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2|
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