Relaxin/insulin-like family peptide receptor 2

Relaxin/insulin-like family peptide receptor 2
Identifiers
Symbols	RXFP2 ; GPR106; GREAT; INSL3R; LGR8; LGR8.1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 15402
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human gene.

The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily.[supplied by OMIM]

See also

• Relaxin receptor

Further reading

• Bathgate RA, Ivell R, Sanborn BM; et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bathgate RA, Ivell R, Sanborn BM; et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu SY, Nakabayashi K, Nishi S; et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumagai J, Hsu SY, Matsumi H; et al. (2002). "INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent". J. Biol. Chem. 277 (35): 31283–6. doi:10.1074/jbc.C200398200. PMID 12114498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorlov IP, Kamat A, Bogatcheva NV; et al. (2003). "Mutations of the GREAT gene cause cryptorchidism". Hum. Mol. Genet. 11 (19): 2309–18. PMID 12217959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sudo S, Kumagai J, Nishi S; et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferlin A, Simonato M, Bartoloni L; et al. (2003). "The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism". J. Clin. Endocrinol. Metab. 88 (9): 4273–9. PMID 12970298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roh J, Virtanen H, Kumagai J; et al. (2004). "Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism". Reprod. Biomed. Online. 7 (4): 400–6. PMID 14656401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vinci G, Anjot MN, Trivin C; et al. (2005). "An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia". J. Clin. Endocrinol. Metab. 89 (12): 6282–5. doi:10.1210/jc.2004-0891. PMID 15579790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Büllesbach EE, Schwabe C (2005). "LGR8 signal activation by the relaxin-like factor". J. Biol. Chem. 280 (15): 14586–90. doi:10.1074/jbc.M414443200. PMID 15708846.
• Muda M, He C, Martini PG; et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosengren KJ, Zhang S, Lin F; et al. (2006). "Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3". J. Biol. Chem. 281 (38): 28287–95. doi:10.1074/jbc.M603829200. PMID 16867980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bogatcheva NV, Ferlin A, Feng S; et al. (2007). "T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane". Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. doi:10.1152/ajpendo.00228.2006. PMID 16926383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott DJ, Layfield S, Yan Y; et al. (2007). "Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules". J. Biol. Chem. 281 (46): 34942–54. doi:10.1074/jbc.M602728200. PMID 16963451.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• El Houate B, Rouba H, Sibai H; et al. (2007). "Novel mutations involving the INSL3 gene associated with cryptorchidism". J. Urol. 177 (5): 1947–51. doi:10.1016/j.juro.2007.01.002. PMID 17437853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott DJ, Wilkinson TN, Zhang S; et al. (2007). "Defining the LGR8 residues involved in binding insulin-like peptide 3". Mol. Endocrinol. 21 (7): 1699–712. doi:10.1210/me.2007-0097. PMID 17473281.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.